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ATP-binding cassette sub-family B member 8 (ABCB8) Recombinant Protein | ABCB8 recombinant protein
Recombinant Human ATP-binding cassette sub-family B member 8, mitochondrial (ABCB8)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
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NCBI and Uniprot Product Information
NCBI Description
This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Description
ABCB8: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes. [provided by RefSeq, Jul 2008]
Protein type: Transporter, ABC family; Membrane protein, multi-pass; Transporter; Mitochondrial; Hydrolase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q36
Cellular Component: ATP-binding cassette (ABC) transporter complex; membrane; mitochondrial envelope; mitochondrial inner membrane; mitochondrion; nucleolus; nucleus
Molecular Function: ATP binding; ATPase activity, coupled to transmembrane movement of substances; transporter activity
Biological Process: metabolic process; transmembrane transport; transport
Research Articles on ABCB8
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Product Notes
The ABCB8 abcb8 (Catalog #AAA7007110) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 38-693aa; Partial. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the ABCB8 abcb8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: GKTGQLHKAE GEYSDGYRSS SLLRAVAHLR SQLWAHLPRA PLAPRWSPSA WCWVGGALLG PMVLSKHPHL CLVALCEAEE APPASSTPHV VGSRFNWKLF WQFLHPHLLV LGVAVVLALG AALVNVQIPL LLGQLVEVVA KYTRDHVGSF MTESQNLSTH LLILYGVQGL LTFGYLVLLS HVGERMAVDM RRALFSSLLR QDITFFDANK TGQLVSRLTT DVQEFKSSFK LVISQGLRSC TQVAGCLVSL SMLSTRLTLL LMVATPALMG VGTLMGSGLR KLSRQCQEQI ARAMGVADEA LGNVRTVRAF AMEQREEERY GAELEACRCR AEELGRGIAL FQGLSNIAFN CMVLGTLFIG GSLVAGQQLT GGDLMSFLVA SQTVQRSMAN LSVLFGQVVR GLSAGARVFE YMALNPCIPL SGGCCVPKEQ LRGSVTFQNV CFSYPCRPGF EVLKDFTLTL PPGKIVALVG QSGGGKTTVA SLLERFYDPT AGVVMLDGRD LRTLDPSWLR GQVVGFISQE PVLFGTTIME NIRFGKLEAS DEEVYTAARE ANAHEFITSF PEGYNTVVGE RGTTLSGGQK QRLAIARALI KQPTVLILDE ATSALDAESE RVVQEALDRA SAGRTVLVIA HRLSTVRGAH CIVVMADGRV WEAGTH. It is sometimes possible for the material contained within the vial of "ATP-binding cassette sub-family B member 8 (ABCB8), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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