Rabbit anti-Human 26S proteasome non-ATPase regulatory subunit 11 Polyclonal Antibody | anti-PSMD11 antibody

26S proteasome non-ATPase regulatory subunit 11 Polyclonal Antibody

Cat. Num. AAA9415080

• Gene Names: PSMD11; S9; Rpn6; p44.5
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Caprylic Acid Ammonium Sulfate Precipitation purified
• Synonyms: 26S proteasome non-ATPase regulatory subunit 11; Polyclonal Antibody; 26S proteasome non-ATPase regulatory subunit 11 Polyclonal Antibody; PSMD11; 26S proteasome regulatory subunit RPN6; 26S proteasome regulatory subunit S9; 26S proteasome regulatory subunit p44.5; anti-PSMD11 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total 26S proteasome non-ATPase regulatory subunit 11 polyclonal antibody.
• Purity/Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
• Form/Format: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 422

• Applicable Applications for anti-PSMD11 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western Blot: 1:500 - 1:1000; Immunohistochemistry: 1:20 - 1:200
• Immunogen: Recombinant Human 26S proteasome non-ATPase regulatory subunit 11 protein
• Immunogen Type: Protein
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(All lanes: 26S proteasome non-ATPase regulatory subunit 11 antibody at 2ug/ml+EC109 whole cell lysate)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embeded human prostate using at dilution of 1:100.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embeded human placenta using at dilution of 1:100.)

Related Product Information for anti-PSMD11 antibody

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits.Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator.

Product Categories/Family for anti-PSMD11 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 394953908
• NCBI GeneID: 5717
• NCBI Accession #: NP_001257411.1
• NCBI GenBank Nucleotide #: NM_001270482.1
• UniProt Accession #: O00231; O00495; Q53FT5; A8K3I7; E1P663
• Molecular Weight: 47,535 Da
• NCBI Official Full Name: 26S proteasome non-ATPase regulatory subunit 11
• NCBI Official Synonym Full Names: proteasome 26S subunit, non-ATPase 11
• NCBI Official Symbol: PSMD11
• NCBI Official Synonym Symbols: S9; Rpn6; p44.5
• NCBI Protein Information: 26S proteasome non-ATPase regulatory subunit 11
• UniProt Protein Name: 26S proteasome non-ATPase regulatory subunit 11
• Protein Family: 26S proteasome non-ATPase regulatory
• UniProt Gene Name: PSMD11
• UniProt Entry Name: PSD11_HUMAN

Uniprot Description

PSMD11: Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. Belongs to the proteasome subunit S9 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Proteasome complex

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: cytosol; membrane; nucleoplasm; nucleus; proteasome complex

Molecular Function: protein binding; structural molecule activity

Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; proteasome assembly; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; stem cell differentiation; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway, planar cell polarity pathway