Mouse polymerase (RNA) I polypeptide C, 30kDa ELISA Kit | POLR1C elisa kit
Mouse DNA-directed RNA polymerases I and III subunit RPAC1, POLR1C ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
RPA40: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft. Defects in POLR1C are the cause of Treacher Collins syndrome type 3 (TCS3). A form of Treacher Collins syndrome, a disorder of craniofacial development. Treacher Collins syndrome is characterized by a combination of bilateral downward slanting of the palpebral fissures, colobomas of the lower eyelids with a paucity of eyelashes medial to the defect, hypoplasia of the facial bones, cleft palate, malformation of the external ears, atresia of the external auditory canals, and bilateral conductive hearing loss. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transferase; EC 2.7.7.6; Transcription initiation complex; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine
Cellular Component: DNA-directed RNA polymerase III complex; nucleus; DNA-directed RNA polymerase I complex
Molecular Function: protein dimerization activity; DNA binding; DNA-directed RNA polymerase activity
Biological Process: transcription, DNA-dependent