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Mouse polymerase (RNA) I polypeptide C, 30kDa ELISA Kit | POLR1C elisa kit

Mouse DNA-directed RNA polymerases I and III subunit RPAC1, POLR1C ELISA Kit

Gene Names
Polr1c; 40kDa; RPA40; Polr1e; Rpo1-1; AA409007; AA959927; AL024089
Reactivity
Mouse
Synonyms
polymerase (RNA) I polypeptide C; 30kDa; Mouse DNA-directed RNA polymerases I and III subunit RPAC1; POLR1C ELISA Kit; Mouse DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) ELISA kit; RP3-337H4.4; RPA39; RPA40; RPA5; RPAC1; RNA polymerase I subunit; POLR1C elisa kit
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For Research Use Only!
Reactivity
Mouse
Preparation and Storage
Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
39,107 Da
NCBI Official Full Name
DNA-directed RNA polymerases I and III subunit RPAC1
NCBI Official Synonym Full Names
polymerase (RNA) I polypeptide C
NCBI Official Symbol
Polr1c
NCBI Official Synonym Symbols
40kDa; RPA40; Polr1e; Rpo1-1; AA409007; AA959927; AL024089
NCBI Protein Information
DNA-directed RNA polymerases I and III subunit RPAC1; AC40; RPC40; RNA polymerase 1-1 (40 kDa subunit); RNA polymerases I and III subunit AC1; DNA-directed RNA polymerase I subunit C; DNA-directed RNA polymerases I and III 40 kDa polypeptide
UniProt Protein Name
DNA-directed RNA polymerases I and III subunit RPAC1
UniProt Gene Name
Polr1c
UniProt Synonym Gene Names
Rpo1-1; DNA-directed RNA polymerase I subunit C; RNA polymerases I and III subunit AC1; RPA40
UniProt Entry Name
RPAC1_MOUSE

Uniprot Description

RPA40: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft. Defects in POLR1C are the cause of Treacher Collins syndrome type 3 (TCS3). A form of Treacher Collins syndrome, a disorder of craniofacial development. Treacher Collins syndrome is characterized by a combination of bilateral downward slanting of the palpebral fissures, colobomas of the lower eyelids with a paucity of eyelashes medial to the defect, hypoplasia of the facial bones, cleft palate, malformation of the external ears, atresia of the external auditory canals, and bilateral conductive hearing loss. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; EC 2.7.7.6; Transcription initiation complex; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine

Cellular Component: DNA-directed RNA polymerase III complex; nucleus; DNA-directed RNA polymerase I complex

Molecular Function: protein dimerization activity; DNA binding; DNA-directed RNA polymerase activity

Biological Process: transcription, DNA-dependent

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Product Notes

The Mouse POLR1C polr1c (Catalog #AAA9335071) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9335071 ELISA Kit recognizes Mouse POLR1C. It is sometimes possible for the material contained within the vial of "polymerase (RNA) I polypeptide C, 30kDa, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.
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