DNA-directed RNA polymerase I subunit RPA1 (POLR1A) Recombinant Protein | POLR1A recombinant protein
Recombinant Human DNA-directed RNA polymerase I subunit RPA1 (POLR1A) , partial
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis. [provided by RefSeq, May 2016]
Uniprot Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition ().
Research Articles on POLR1A
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Product Notes
The POLR1A polr1a (Catalog #AAA1056774) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1198-1497, Partial. The amino acid sequence is listed below: LKWQRSLCEP GEAVGLLAAQ SIGEPSTQMT LNTFHFAGRG EMNVTLGIPR LREILMVASA NIKTPMMSVP VLNTKKALKR VKSLKKQLTR VCLGEVLQKI DVQESFCMEE KQNKFQVYQL RFQFLPHAYY QQEKCLRPED ILRFMETRFF KLLMESIKKK NNKASAFRNV NTRRATQRDL DNAGELGRSR GEQEGDEEEE GHIVDAEAEE GDADASDAKR KEKQEEEVDY ESEEEEEREG EENDDEDMQE ERNPHREGAR KTQEQDEEVG LGTEEDPSLP ALLTQPRKPT HSQEPQGPEA . It is sometimes possible for the material contained within the vial of "DNA-directed RNA polymerase I subunit RPA1 (POLR1A), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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