Western Blot (WB)
(Western blot analysis of POLR1A expression in A375 (A), HEK293T (B), NIH3T3 (C), H9C2 (D) whole cell lysates.)
Rabbit POLR1A Polyclonal Antibody | anti-POLR1A antibody
Anti-POLR1A Antibody
Western Blot (WB)
(Western blot analysis of POLR1A expression in A375 (A), HEK293T (B), NIH3T3 (C), H9C2 (D) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of POLR1A expression in A375 (A), HEK293T (B), NIH3T3 (C), H9C2 (D) whole cell lysates.)
NCBI and Uniprot Product Information
Uniprot Description
POLR1A: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. Belongs to the RNA polymerase beta' chain family.
Protein type: Nucleotide Metabolism - pyrimidine; Transferase; Transcription initiation complex; Nucleotide Metabolism - purine; Nucleolus; EC 2.7.7.6
Chromosomal Location of Human Ortholog: 2p11.2
Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus; DNA-directed RNA polymerase I complex
Molecular Function: protein binding; DNA binding; zinc ion binding
Biological Process: negative regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; transcription from RNA polymerase I promoter; gene expression; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter; regulation of gene expression, epigenetic
Disease: Acrofacial Dysostosis, Cincinnati Type
Research Articles on POLR1A
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Product Notes
The POLR1A polr1a (Catalog #AAA822276) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-POLR1A Antibody reacts with Human, Mouse, Rat, Monkey and may cross-react with other species as described in the data sheet. AAA Biotech's POLR1A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB (1/500 - 1/1000). Researchers should empirically determine the suitability of the POLR1A polr1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "POLR1A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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