Phosphomevalonate Kinase/PMVK Recombinant Protein | PMVK recombinant protein

Recombinant Human Phosphomevalonate Kinase/PMVK Protein (N-6His)

Cat. Num. AAA2553089

• Gene Names: PMVK; PMK; PMKA; PMKASE; POROK1; HUMPMKI
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Phosphomevalonate Kinase/PMVK; Recombinant Human Phosphomevalonate Kinase/PMVK Protein (N-6His); Phosphomevalonate Kinase; PMKase; hPMK; PMVK; PMKI; PMVK recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Supplied as a 0.2 mum filtered solution of 20mM Tris HCl, 100mM NaCl, 1mM DTT, 10% Glycerol, pH 7.5.
• Sequence Positions: Met1-Leu192
• Sequence Length: 192

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: N-6His
• Preparation and Storage: Store at < -20 degree C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.

Related Product Information for PMVK recombinant protein

Phosphomevalonate kinase (PMVK) is a cytosolic enzyme. PMVK can be highly expressed in the heart, skeletal muscle, liver, pancreas, and kidney; it is expressed at lower levels in the brain, lung, and placenta. Induced by sterol, PMVK takes part in isopentenyl diphosphate biosynthesis through the mevalonate pathway. PMVK catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate in the fifth reaction of the cholesterol biosynthetic pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 5729980
• NCBI GeneID: 10654
• NCBI Accession #: NP_006547.1
• NCBI GenBank Nucleotide #: NM_006556.3
• UniProt Accession #: Q15126; Q5TZW9
• Molecular Weight: Molecular Mass: 24.2 kDa; Actual Protein Molecular Mass: 26 kDa
• NCBI Official Full Name: phosphomevalonate kinase isoform 1
• NCBI Official Synonym Full Names: phosphomevalonate kinase
• NCBI Official Symbol: PMVK
• NCBI Official Synonym Symbols: PMK; PMKA; PMKASE; POROK1; HUMPMKI
• NCBI Protein Information: phosphomevalonate kinase
• UniProt Protein Name: Phosphomevalonate kinase
• UniProt Gene Name: PMVK
• UniProt Synonym Gene Names: PMKI; PMKase; hPMK

NCBI Description

This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Uniprot Description

CautionWas originally thought to be located in the peroxisome (PubMed:10191291). However, was later shown to be cytosolic (PubMed:14729858, PubMed:27052676).