Mouse polo-like kinase 3 (Drosophila) ELISA Kit | PLK3 elisa kit
Mouse Serine/threonine-protein kinase PLK3, PLK3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal catalytic domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases have primarily been implicated in cell cycle regulation. In mouse, this protein that has been reported to localize to the nucleolus during interphase but is undetectable during mitosis, following nucleolus dissociation during prophase. The protein relocalizes to the nucleolus just prior to cytokinesis and peak levels are detected during G1 of interphase. This gene has been implicated in regulation of entry into S phase, with RNAi-induced depletion resulting in failure to re-enter the cell cycle. Mice deficient for this gene exhibit increased weight and tumor development at advanced age. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Uniprot Description
PLK3: a kinase of the PLK family. Phosphorylated and activated following DNA damage or mitotic spindle disruption. Interacts with Chk2 and the interaction is enhanced upon DNA damage. Apparent substrates include Chk2 and p53. Plays an important role in regulating microtubule dynamics and centrosomal function. Deregulated expression of Plk3 results in cell cycle arrest and apoptosis.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.21; Kinase, protein; Nucleolus; Protein kinase, Other; Other group; PLK family
Cellular Component: Golgi apparatus; centrosome; Golgi stack; cytoskeleton; cell soma; dendrite; cytoplasm; nucleolus; intracellular; nucleus; chromatin
Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; p53 binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity
Biological Process: apoptosis; negative regulation of transcription from RNA polymerase II promoter; cell cycle; response to osmotic stress; regulation of cytokinesis; protein amino acid phosphorylation; cytoplasmic microtubule organization and biogenesis; response to reactive oxygen species; response to radiation; protein kinase B signaling cascade; regulation of cell division; response to DNA damage stimulus; phosphorylation; G1/S transition of mitotic cell cycle; negative regulation of apoptosis
Research Articles on PLK3
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Product Notes
The Mouse PLK3 plk3 (Catalog #AAA9342726) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9342726 ELISA Kit recognizes Mouse PLK3. It is sometimes possible for the material contained within the vial of "polo-like kinase 3 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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