SDS-PAGE
PLAUR / CD87 / uPAR recombinant protein
Recombinant Mouse PLAUR / CD87 / uPAR Protein (His tag)
Gene Names
Plaur; Cd87; uPAR; u-PAR
Purity
> 97 % as determined by SDS-PAGE
Synonyms
PLAUR / CD87 / uPAR; Recombinant Mouse PLAUR / CD87 / uPAR Protein (His tag); Plaur; Cd87; uPAR; PLAUR / CD87 / uPAR recombinant protein
Host
Human Cells
Purity/Purification
> 97 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
327
Application Notes
The recombinant mouse PLAUR comprises 285 amino acids and has a predicted molecular mass of 31.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmPLAUR is approximately 50-60 kDa due to glycosylation.
Predicted N Terminal
Leu 24
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for PLAUR / CD87 / uPAR recombinant protein
Background: Urokinase plasminogen activator (uPA) and/or its receptor (uPAR) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumours. uPAR and uPA levels in both resected tumor tissue and plasma are of independent prognostic significance for patient survival in several type s of human cancer. This system has classically been thought to drive tumor progression by mediating directed extracellular proteolysis on the surface of migrating or invading cells, and intervening with this proteolysis by targeting uPAR has been proposed to represent a novel approach for inhibiting tumor progression. uPAR, also known as PLAUR or CD87, has been implicated in the growth, metastasis, and angiogenesis of several solid and hemotologic malignancies. uPAR is a highly glycosylated, 55-60kDa integral membrane protein linked to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. It is part of a cell surface system that also consists of the serine protease uPA and several specific inhibitors (plasminogen activator inhibitors 1 and 2). Additionally, the analysis of CD87 (urokinase-type plasminogen activator receptor - uPAR) expression has a potential role in the prognostic work-up of several hematological malignancies, particularly acute leukemia and multiple myeloma.
Description: A DNA sequence encoding the extracellular domain of mouse PLAUR (NP_035243.1) precursor (Met 1-Thr 297) was expressed, fused with a polyhistidine tag at the C-terminus.
Description: A DNA sequence encoding the extracellular domain of mouse PLAUR (NP_035243.1) precursor (Met 1-Thr 297) was expressed, fused with a polyhistidine tag at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
24,619 Da
NCBI Official Full Name
urokinase plasminogen activator surface receptor
NCBI Official Synonym Full Names
plasminogen activator, urokinase receptor
NCBI Official Symbol
Plaur
NCBI Official Synonym Symbols
Cd87; uPAR; u-PAR
NCBI Protein Information
urokinase plasminogen activator surface receptor
UniProt Protein Name
Urokinase plasminogen activator surface receptor
UniProt Gene Name
Plaur
UniProt Synonym Gene Names
U-PAR; uPAR
Uniprot Description
uPAR: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Expressed in neurons of the rolandic area of the brain. Expressed in the brain. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, GPI anchor; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 7|7 A3
Cellular Component: focal adhesion; integral to plasma membrane; plasma membrane
Molecular Function: enzyme binding; protein binding; protein domain specific binding; receptor binding; U-plasminogen activator receptor activity
Biological Process: mesenchymal cell differentiation; negative regulation of apoptosis; positive regulation of DNA binding; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of protein amino acid phosphorylation
Research Articles on PLAUR / CD87 / uPAR
Similar Products
Product Notes
The PLAUR / CD87 / uPAR plaur (Catalog #AAA2547134) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant mouse PLAUR comprises 285 amino acids and has a predicted molecular mass of 31.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmPLAUR is approximately 50-60 kDa due to glycosylation. Researchers should empirically determine the suitability of the PLAUR / CD87 / uPAR plaur for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PLAUR / CD87 / uPAR, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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