NCBI Description
This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]
Uniprot Description
CDA: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Belongs to the cytidine and deoxycytidylate deaminase family.
Protein type: Xenobiotic Metabolism - drug metabolism - other enzymes; Hydrolase; EC 3.5.4.5; Nucleotide Metabolism - pyrimidine
Chromosomal Location of Human Ortholog: 1p36.2-p35
Cellular Component: cytosol; extracellular region
Molecular Function: cytidine deaminase activity; nucleoside binding; protein binding; protein homodimerization activity; zinc ion binding
Biological Process: cytidine deamination; cytosine metabolic process; negative regulation of cell growth; negative regulation of nucleotide metabolic process; protein homotetramerization; pyrimidine nucleoside salvage
Product Notes
The Plant CDA cda (Catalog #
AAA9370692) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9370692 ELISA Kit recognizes Plant CDA.
It is sometimes possible for the material contained within the vial of
"Cytidine Deaminase (CDA), ELISA Kit" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech
cannot be held
responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
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of any product performance
issues observed or experienced within 30 days of receipt of said product. To see additional
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