PKA IIbeta reg Blocking Peptide | PKAIibeta blocking peptide

PKA IIbeta reg (T109) Peptide

Cat. Num. AAA3003567

• Gene Names: PRKAR2B; PRKAR2; RII-BETA
• Applications: Blocking
• Purity: Synthetic peptide PKA IIbeta reg (T109). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: PKA IIbeta reg; PKA IIbeta reg (T109) Peptide; PRKAR2B; PKAIibeta blocking peptide

• Specificity: This peptide can be used with studies using MBS3003566 PKA IIbeta reg (T109) pAb.
• Purity/Purification: Synthetic peptide PKA IIbeta reg (T109). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 418

• Applicable Applications for PKAIibeta blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for PKAIibeta blocking peptide

The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified, designated Calpha, Cbeta and Cgamma, that each represent specific gene products. Calpha and Cbeta are closely related (93% amino acid sequence similarity), whereas Cgamma displays 83% and 79% similarity to Calpha and Cbeta, respectively.

NCBI and Uniprot Product Information

• NCBI GI #: 47132585
• NCBI GeneID: 5577
• NCBI Accession #: NP_002727.2
• NCBI GenBank Nucleotide #: NP_002727.2
• UniProt Accession #: P31323
• NCBI Official Full Name: cAMP-dependent protein kinase type II-beta regulatory subunit
• NCBI Official Synonym Full Names: protein kinase cAMP-dependent type II regulatory subunit beta
• NCBI Official Symbol: PRKAR2B
• NCBI Official Synonym Symbols: PRKAR2; RII-BETA
• NCBI Protein Information: cAMP-dependent protein kinase type II-beta regulatory subunit
• UniProt Protein Name: cAMP-dependent protein kinase type II-beta regulatory subunit
• UniProt Gene Name: PRKAR2B
• UniProt Entry Name: KAP3_HUMAN

NCBI Description

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008]

Uniprot Description

PKAR2B: a regulatory subunit of cAMP-regulated protein kinase. The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.

Protein type: Mitochondrial; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: centrosome; cytoplasm; dendritic spine; plasma membrane; dendritic shaft; cytosol; cAMP-dependent protein kinase complex

Molecular Function: ubiquitin protein ligase binding; cAMP-dependent protein kinase inhibitor activity; cAMP-dependent protein kinase regulator activity; cAMP binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; organelle organization and biogenesis; activation of protein kinase A; learning; fatty acid metabolic process; signal transduction; phospholipase C activation; energy reserve metabolic process; innate immune response; renal water homeostasis; mitotic cell cycle; blood coagulation; G2/M transition of mitotic cell cycle; transmembrane transport; regulation of insulin secretion