Mouse paired-like homeodomain 2 ELISA Kit | PITX2 elisa kit
Mouse Pituitary homeobox 2, PITX2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
PITX2: Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo. Defects in PITX2 are the cause of Axenfeld-Rieger syndrome type 1 (RIEG1); also known as Rieger syndrome type 1. RIEG1 is an autosomal dominant defect characterized by hypodontia (partial anodontia), anal stenosis, hypertelorism, mental deficiency, agenesis of the facial bones, with malformation of the anterior chamber of the eye. Defects in PITX2 are the cause of iridogoniodysgenesis type 2 (IRID2); also known as iridogoniodysgenesis syndrome 2 (IGDS2). It is an autosomal dominant inherited disease. Defects in PITX2 are a cause of Peters anomaly (PAN). It is a congenital defect of the anterior chamber of the eye. Defects in PITX2 are associated with ring dermoid of cornea (RDC). RDC is an autosomal dominantly inherited syndrome characterized by bilateral annular limbal dermoids with corneal and conjunctival extension. Belongs to the paired homeobox family. Bicoid subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; DNA-binding; Transcription factor; Motility/polarity/chemotaxis
Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; DNA binding; sequence-specific DNA binding; chromatin DNA binding; phosphoprotein binding; chromatin binding; transcription factor binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; atrial cardiac muscle morphogenesis; positive regulation of transcription, DNA-dependent; heart development; multicellular organismal development; ventricular cardiac muscle cell development; neuron migration; negative regulation of transcription from RNA polymerase II promoter; regulation of cell migration; embryonic hindlimb morphogenesis; cardiac muscle cell differentiation; odontogenesis; regulation of transcription, DNA-dependent; embryonic digestive tract morphogenesis; extraocular skeletal muscle development; vasculogenesis; hypothalamus cell migration; myoblast fusion; positive regulation of DNA binding; cardiac muscle development; spleen development; anatomical structure morphogenesis; skeletal muscle development; Wnt receptor signaling pathway; camera-type eye development; in utero embryonic development; embryonic camera-type eye development; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; patterning of blood vessels; organ morphogenesis; subthalamic nucleus development; pituitary gland development; positive regulation of transcription from RNA polymerase II promoter; determination of left/right symmetry; lung development
Research Articles on PITX2
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Product Notes
The Mouse PITX2 pitx2 (Catalog #AAA9328365) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9328365 ELISA Kit recognizes Mouse PITX2. It is sometimes possible for the material contained within the vial of "paired-like homeodomain 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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