PILRA recombinant protein

PILRA Protein, Human, Recombinant

Cat. Num. AAA8121537

• Gene Names: PILRA; FDF03
• Purity: >85% as determined by SDS-PAGE
• Synonyms: PILRA; PILRA Protein; Human; Recombinant; Human PILR-alpha/PILRA Protein; FDF03 Protein; paired immunoglobin-like type 2 receptor alpha; PILRA recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >85% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Asp226

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Gln 20
• Tag: C-cleavage
• Protein Construction: A DNA sequence encoding the human PILRA (AAH17812.1)(Met1-Asp226) was expressed with five amino acids (DDDDK) at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Product Categories/Family for PILRA recombinant protein

ITIM/ITAM Immunoreceptors and Related Molecules

NCBI and Uniprot Product Information

• NCBI GI #: 17389562
• NCBI GeneID: 29992
• Molecular Weight: 18 kDa (MW of target protein)
• NCBI Official Full Name: PILRA protein
• NCBI Official Synonym Full Names: paired immunoglobin-like type 2 receptor alpha
• NCBI Official Symbol: PILRA
• NCBI Official Synonym Symbols: FDF03
• NCBI Protein Information: paired immunoglobulin-like type 2 receptor alpha
• Protein Family: Paired immunoglobulin-like type 2 receptor

NCBI Description

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008]