LILRB3 recombinant protein

LILRB3 Protein, Mouse, Recombinant (His Tag)

Cat. Num. AAA8122973

• Gene Names: Pirb; Gp91; LIR-3; PIR-B; Lilrb3
• Purity: >95% as determined by SDS-PAGE
• Synonyms: LILRB3; LILRB3 Protein; Mouse; Recombinant (His Tag); Mouse LILRB3/LIR3/ILT5/CD85a Protein (His Tag); Gp91 Protein; Pirb Protein; leukocyte immunoglobulin like receptor B3; LILRB3 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Tyr640

• Species: Mouse
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Ser 25
• Tag: C-His
• Protein Construction: A DNA sequence encoding the extracellular domain of mouse LILRB3 (AAC53219.1)(Met 1-Tyr 640), was fused with a C-terminal polyhistidine tag.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for LILRB3 recombinant protein

Background: Leukocyte immunoglobulin-like receptor subfamily B member 3, also known as Leukocyte immunoglobulin-like receptor 3, Immunoglobulin-like transcript 5, Monocyte inhibitory receptor HL9, CD85 antigen-like family member A, CD85a and LILRB3, is a single-pass type I membrane protein that belongs to the leukocyte receptor cluster (LRC) present on 19q13.4. LILRB3/CD85a contains four Ig-like C2-type (immunoglobulin-like) domains. LILRB3/CD85a contains three copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in the modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. LILRB3/CD85a is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found.

Product Categories/Family for LILRB3 recombinant protein

ITIM/ITAM Immunoreceptors and Related Molecules

References

Huang,J. et al., 2010, J Virol. 84 (18): 9463-71. Arm J.P. et al., 1997, J. Immunol. 159:2342-2349. Wende H. et al., 2000, Immunogenetics 51:703-713. Yu L.-R. et al., 2007,J. Proteome Res. 6:4150-4162.

NCBI and Uniprot Product Information

• NCBI GI #: 2138367
• NCBI GeneID: 18733
• Molecular Weight: 93,054 Da
• NCBI Official Full Name: PIRB1
• NCBI Official Synonym Full Names: paired Ig-like receptor B
• NCBI Official Symbol: Pirb
• NCBI Official Synonym Symbols: Gp91; LIR-3; PIR-B; Lilrb3
• NCBI Protein Information: leukocyte immunoglobulin-like receptor subfamily B member 3
• Protein Family: Leukocyte immunoglobulin-like receptor subfamily