PEX26 recombinant protein

PEX26, 1-246aa, Human, His tag, E Coli

Cat. Num. AAA204933

• Gene Names: PEX26; PBD7A; PBD7B; PEX26M1T; Pex26pM1T
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: PEX26; 1-246aa; Human; His tag; E Coli; Peroxisome assembly protein 26; PBD7A; PBD7B; PEX26M1T; Pex26pM1T; PEX26 recombinant protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT
• Concentration: 0.5 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMKSDSST SAAPLRGLGG PLRSSEPVRA VPARAPAVDL LEEAADLLVV HLDFRAALET CERAWQSLAN HAVAEEPAGT SLEVKCSLCV VGIQALAEMD RWQEVLSWVL QYYQVPEKLP PKVLELCILL YSKMQEPGAV LDVVGAWLQD PANQNLPEYG ALAEFHVQRV LLPLGCLSEA EELVVGSAAF GEERRLDVLQ AIHTARQQQK QEHSGSEEAQ KPNLEGSVSH KFLSLPMLVR QLWDSAVSH
• Sequence Length: 305

• Applicable Applications for PEX26 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for PEX26 recombinant protein

PEX26 belongs to the peroxin-26 gene family. It is probably required for protein import into peroxisomes. It anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Defects in this gene are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. Recombinant human PEX26 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for PEX26 recombinant protein

Signal Transduction

References

Matsumoto N., et al. (2003) Nat. Cell Biol. 5:454-460; Matsumoto N., et al. (2003) Am. J. Hum. Genet. 73:233-246;

NCBI and Uniprot Product Information

• NCBI GI #: 189083737
• NCBI GeneID: 55670
• NCBI Accession #: NP_001121121
• NCBI GenBank Nucleotide #: NM_001127649.2
• UniProt Accession #: Q7Z412; Q7Z413; Q7Z414; Q7Z415; Q7Z416; Q96B12; Q9NWQ0; Q9NXU0; F6UBB5
• Molecular Weight: 29.3 kDa (269aa), confirmed by MALDI-TOF
• NCBI Official Full Name: peroxisome assembly protein 26 isoform a
• NCBI Official Synonym Full Names: peroxisomal biogenesis factor 26
• NCBI Official Symbol: PEX26
• NCBI Official Synonym Symbols: PBD7A; PBD7B; PEX26M1T; Pex26pM1T
• NCBI Protein Information: peroxisome assembly protein 26
• UniProt Protein Name: Peroxisome assembly protein 26
• Protein Family: Peroxisome assembly protein
• UniProt Gene Name: PEX26

NCBI Description

This gene belongs to the peroxin-26 gene family. It is probably required for protein import into peroxisomes. It anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Defects in this gene are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Dec 2010]

Uniprot Description

Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence.