TL1A Peptide | TNFSF15 peptide

TL1A (Control Peptide) (TNFSF15, Tumor Necrosis Factor Ligand Superfamily Member 15)

Cat. Num. AAA659386

• Gene Names: TNFSF15; TL1; TL1A; VEGI; VEGI192A
• Applications: ELISA, Western Blot
• Purity: Purified; Purified
• Synonyms: TL1A; TL1A (Control Peptide) (TNFSF15; Tumor Necrosis Factor Ligand Superfamily Member 15); TNFSF15 peptide

• Purity/Purification: Purified; Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.02% sodium azide.

• Applicable Applications for TNFSF15 peptide: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: The peptide is used for blocking the activity of TL1A (NT) antibody. It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37 degree C.
• Location: 14aa near the amino terminus of human TL1A (1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for TNFSF15 peptide

TL1A, also known as tumor necrosis factor ligand superfamily member 15 (TNFSF15). TL1A acts as a co-stimulator of IFN-gamma secretion through binding to DR3 (death domain receptor 3 or TRAMP) and may play an important role in Th1-mediated diseases such as Crohn's disease. In cells expressing DR3, TL1A induces NF-kappa-B activation and apoptosis. Decoy receptor 3 (DcR3) is also a receptor for TL1A. DcR3 can apparently neutralise the effect of TL1A, by inhibiting the TL1A-DR3 interaction, thereby inhibiting apoptosis. TL1A is specifically expressed on endothelial cells and is detected on monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.

Product Categories/Family for TNFSF15 peptide

Molecular Biology; MB-Peptides

NCBI and Uniprot Product Information

• NCBI GI #: 23510445
• NCBI GeneID: 9966
• NCBI Accession #: NP_005109.2
• NCBI GenBank Nucleotide #: NM_005118.3
• UniProt Accession #: O95150; Q3SX69; Q5VJK8; Q5VWH1; Q8NFE9
• Molecular Weight: 28,087 Da
• NCBI Official Full Name: tumor necrosis factor ligand superfamily member 15 isoform VEGI-251
• NCBI Official Synonym Full Names: tumor necrosis factor (ligand) superfamily, member 15
• NCBI Official Symbol: TNFSF15
• NCBI Official Synonym Symbols: TL1; TL1A; VEGI; VEGI192A
• NCBI Protein Information: tumor necrosis factor ligand superfamily member 15; TNF superfamily ligand TL1A; TNF ligand-related molecule 1; vascular endothelial cell growth inhibitor; vascular endothelial growth inhibitor-192A
• UniProt Protein Name: Tumor necrosis factor ligand superfamily member 15
• Protein Family: Tumor necrosis factor ligand superfamily
• UniProt Gene Name: TNFSF15
• UniProt Synonym Gene Names: TL1; VEGI
• UniProt Entry Name: TNF15_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Uniprot Description

Function: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Ref.1 Ref.2 Ref.3 Ref.9

Subunit structure: Homotrimer. Ref.10

Subcellular location: Membrane; Single-pass type II membrane protein

Probable Ref.2 Ref.3. Tumor necrosis factor ligand superfamily member 15, secreted form: Secreted Ref.2 Ref.3.

Tissue specificity: Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. Ref.1 Ref.2 Ref.3 Ref.8

Induction: Up-regulated by IL1A/interleukin-1 alpha and TNF. Ref.2 Ref.3

Sequence similarities: Belongs to the tumor necrosis factor family.