Human Bone morphogenetic protein 7 ELISA Kit | BMP7 elisa kit

Human Bone morphogenetic protein 7 ELISA Kit

Cat. Num. AAA288657

• Gene Names: BMP7; OP-1
• Reactivity: Human
• Synonyms: Bone morphogenetic protein 7; Human Bone morphogenetic protein 7 ELISA Kit; BMP-7; Osteogenic protein 1; OP-1; BMP7; OP1; BMP7 elisa kit

• Reactivity: Human
• Sequence Length: 431

• Assay Type: Sandwich
• Detection Range: 31.2-2000 pg/mL
• Sensitivity: 10pg/mL
• Intra-Assay CV: <=4.3%
• Inter-Assay CV: <=6.5%
• Recovery: 80%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 4502427
• NCBI GeneID: 655
• NCBI Accession #: NP_001710.1
• NCBI GenBank Nucleotide #: NM_001719.2
• UniProt Accession #: P18075; Q9H512; Q9NTQ7
• Molecular Weight: 49,313 Da
• NCBI Official Full Name: bone morphogenetic protein 7 preproprotein
• NCBI Official Synonym Full Names: bone morphogenetic protein 7
• NCBI Official Symbol: BMP7
• NCBI Official Synonym Symbols: OP-1
• NCBI Protein Information: bone morphogenetic protein 7
• UniProt Protein Name: Bone morphogenetic protein 7
• Protein Family: Bone morphogenetic protein
• UniProt Gene Name: BMP7
• UniProt Synonym Gene Names: OP1; BMP-7; OP-1
• UniProt Entry Name: BMP7_HUMAN

NCBI Description

This gene encodes a member of the transforming growth factor-beta (TGF-beta) family of proteins. The encoded preproprotein is proteolytically processed to generate each subunit of the mature homodimer, which plays a role in bone, kidney and brown adipose tissue development. This protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Nov 2015]

Uniprot Description

BMP7: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. Expressed in the kidney and bladder. Lower levels seen in the brain. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q13

Cellular Component: extracellular matrix; extracellular region; extracellular space

Molecular Function: cytokine activity; growth factor activity; heparin binding; protein binding; transforming growth factor beta receptor binding

Biological Process: axon guidance; BMP signaling pathway; branching morphogenesis of a tube; cartilage development; dendrite development; embryonic camera-type eye morphogenesis; embryonic limb morphogenesis; embryonic pattern specification; epithelial cell differentiation; epithelial to mesenchymal transition; extracellular matrix organization and biogenesis; growth; inhibition of NF-kappaB transcription factor; mesenchymal cell differentiation; mesoderm formation; mesonephros development; metanephros development; negative regulation of cell cycle; negative regulation of MAP kinase activity; negative regulation of mitosis; negative regulation of neuron differentiation; negative regulation of NF-kappaB import into nucleus; negative regulation of Notch signaling pathway; negative regulation of phosphorylation; negative regulation of transcription, DNA-dependent; neurite morphogenesis; odontogenesis of dentine-containing teeth; ossification; positive regulation of apoptosis; positive regulation of bone mineralization; positive regulation of heterotypic cell-cell adhesion; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; response to estradiol stimulus; response to peptide hormone stimulus; response to vitamin D; skeletal development; steroid hormone mediated signaling; ureteric bud development