CARD9 peptide

CARD9 (Blocking Peptide) (Caspase Recruitment Domain)

Cat. Num. AAA658537

• Gene Names: CARD9; CANDF2; hCARD9
• Purity: Molecular Biology Grade
• Synonyms: CARD9; CARD9 (Blocking Peptide) (Caspase Recruitment Domain); CARD9 peptide

• Purity/Purification: Molecular Biology Grade
• Form/Format: Supplied as a liquid at 200ug/ml in PBS, pH7.2 (10mM sodium phosphate monobasic, 10mM sodium phosphate dibasic, 130mM sodium chloride), 0.1% bovine serum albumin, 0.02% sodium azide.

• Preparation and Storage: -20 degree C

Western Blot (WB)

(Western blot analysis of CARD9 expression in human HL-60 cell lysate with C1350P at 1ug /ml.)

Related Product Information for CARD9 peptide

Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, Bcl-10, and ASC. A novel CARD containing protein was recently identified and designated CARD9, which interacts with the CARD activation domain of Bcl-10 (1). CARD9 associates with Bcl-10 and forms a complex within cells. CARD9 induces apoptosis and activates NF-kB. CARD9 is an upstream activator of Bcl-10 and NF-kB signaling.

Synthetic peptide (DRENTTGSDNTDTEGS) corresponding to amino acids 521 to 536 of human CARD9 (1). The sequence is different from that of rat origin by two amino acids (1).

Product Categories/Family for CARD9 peptide

Molecular Biology; MB-Apoptosis; Caspase

NCBI and Uniprot Product Information

• NCBI GI #: 47717131
• NCBI GeneID: 64170
• NCBI Accession #: NP_434700.2
• NCBI GenBank Nucleotide #: NM_052813.4
• UniProt Accession #: Q9H257; Q5SXM5; Q5SXM6; Q9H854
• Molecular Weight: 62,241 Da
• NCBI Official Full Name: caspase recruitment domain-containing protein 9 isoform 1
• NCBI Official Synonym Full Names: caspase recruitment domain family, member 9
• NCBI Official Symbol: CARD9
• NCBI Official Synonym Symbols: CANDF2; hCARD9
• NCBI Protein Information: caspase recruitment domain-containing protein 9
• UniProt Protein Name: Caspase recruitment domain-containing protein 9
• Protein Family: Caspase recruitment domain-containing protein
• UniProt Gene Name: CARD9
• UniProt Synonym Gene Names: hCARD9
• UniProt Entry Name: CARD9_HUMAN

NCBI Description

The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Activates NF-kappa-B via BCL10.

Subunit structure: Self-associates. CARD9 and BCL10 bind to each other by CARD-CARD interaction.

Subcellular location: Cytoplasm.

Tissue specificity: Highly expressed in spleen. Also detected in liver, placenta, lung, peripheral blood leukocytes and in brain.

Involvement in disease: Familial candidiasis 2 (CANDF2) [MIM:212050]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7

Sequence similarities: Contains 1 CARD domain.