Pyridoxal Kinase Recombinant Protein | PDXK recombinant protein

Recombinant Human Pyridoxal Kinase

Cat. Num. AAA144291

• Gene Names: PDXK; PKH; PNK; PRED79; C21orf97; HEL-S-1a; C21orf124
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Pyridoxal Kinase; Recombinant Human Pyridoxal Kinase; PDXK Human; Pyridoxal Kinase Human Recombinant; Pyridoxal kinase; Pyridoxine kinase; PDXK; C21orf124; C21orf97; PKH; PNK; PRED79; FLJ31940; FLJ37311; MGC15873; MGC31754; MGC52346; DKFZp566A071; PDXK recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: The PDXK solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 10% glycerol.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMEEECR VLSIQSHVIR GYVGNRAATF PLQVLGFEID AVNSVQFSNH TGYAHWKGQV LNSDELQELY EGLRLNNMNK YDYVLTGYTR DKSFLAMVVD IVQELKQQNP RLVYVCDPVL GDKWDGEGSM YVPEDLLPVY KEKVVPLADI ITPNQFEAELLSGRKIHSQE EALRVMDMLH SMGPDTVVIT SSDLPSPQGS NYLIVLGSQR RRNPAGSVVM ERIRMDIRKV DAVFVGTGDL FAAMLLAWTH KHPNNLKVAC EKTVSTLHHV LQRTIQCAKA QAGEGVRPSP MQLELRMVQS KRDIEDPEIV VQATVL
• Sequence Length: 312

• Preparation and Storage: PDXK should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Related Product Information for PDXK recombinant protein

Description: PDXK Human Recombinant fused with a 24 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 336 amino acids (1-312 a.a.) and having a molecular mass of 37.6kDa. The PDXK is purified by proprietary chromatographic techniques.

Introduction: PDXK converts vitamin B6 to Pyridoxal-5-phosphate (PLP), which is a vital cofactor in the intermediate metabolism of amino acids and neurotransmitters. PDXK is cytoplasmic and probably acts as a homodimer. The biological validity of the alternatively spliced transcript variants has not been determined.

Product Categories/Family for PDXK recombinant protein

Protein Kinases; Enzymes; Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 4505701
• NCBI GeneID: 8566
• NCBI Accession #: NP_003672.1
• NCBI GenBank Nucleotide #: NM_003681.4
• UniProt Accession #: O00764; Q7Z2Y0; Q9BS02
• Molecular Weight: 26,827 Da
• NCBI Official Full Name: pyridoxal kinase
• NCBI Official Synonym Full Names: pyridoxal (pyridoxine, vitamin B6) kinase
• NCBI Official Symbol: PDXK
• NCBI Official Synonym Symbols: PKH; PNK; PRED79; C21orf97; HEL-S-1a; C21orf124
• NCBI Protein Information: pyridoxal kinase; epididymis secretory sperm binding protein Li 1a; pyridoxamine kinase; pyridoxine kinase; vitamin B6 kinase
• UniProt Protein Name: Pyridoxal kinase
• Protein Family: Pyridoxal kinase
• UniProt Gene Name: PDXK
• UniProt Synonym Gene Names: C21orf124; C21orf97; PKH; PNK
• UniProt Entry Name: PDXK_HUMAN

NCBI Description

The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

PDXK: Required for synthesis of pyridoxal-5-phosphate from vitamin B6. Belongs to the pyridoxine kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cofactor and Vitamin Metabolism - vitamin B6; EC 2.7.1.35; Kinase, other

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: potassium ion binding; sodium ion binding; protein homodimerization activity; zinc ion binding; pyridoxal kinase activity; magnesium ion binding; lithium ion binding; ATP binding; pyridoxal phosphate binding

Biological Process: cell proliferation; vitamin metabolic process; vitamin B6 metabolic process; pyridoxal 5'-phosphate salvage; phosphorylation; water-soluble vitamin metabolic process; pyridoxal phosphate biosynthetic process