Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Pendrin (SLC26A4) Standard Curve.)
Human Pendrin (SLC26A4) ELISA Kit | PDS elisa kit
Human Pendrin (SLC26A4) ELISA Kit
Gene Names
SLC26A4; EVA; PDS; DFNB4; TDH2B
Reactivity
Human
Synonyms
Pendrin (SLC26A4); Human Pendrin (SLC26A4) ELISA Kit; SLC26A4; DFNB4; EVA; TDH2B; pendrin; PDS elisa kit
Reactivity
Human
Specificity
Human Pendrin (SLC26A4) ELISA Kit has high sensitivity and excellent specificity for detection of Human SLC26A4. No significant cross-reactivity or interference between Human SLC26A4 and analogues was observed.
Sequence Length
780
Assay Type
Sandwich ELISA (Quantitative)
Samples
Cell Culture Supernatants, Serum, Plasma, Other Biological Fluids
Detection Method
Colorimetric
Usage Notes
* Do not mix components from different kit lots or use reagents beyond the kit expiration date.
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Preparation and Storage
Store at 2-8 degree C.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Pendrin (SLC26A4) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Pendrin (SLC26A4) Standard Curve.)
Related Product Information for PDS elisa kit
Description: This Human Pendrin (SLC26A4) ELISA Kit employs a two-site sandwich ELISA to quantitate SLC26A4 in samples. An antibody specific for SLC26A4 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any SLC26A4 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for SLC26A4 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of SLC26A4 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Background: Pendrin is an ion exchanger found in the cortical collecting duct.Pendrin is found at the luminal membrane of follicular cells in the thyroid gland. It transports iodine from the cytoplasm to the follicle lumen. Its activity is necessary for production of thyroid hormone.Pendrin is also found in the cells of the inner ear, where its function is not well understood. Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. Pendred syndrome is also characterized by hypothyroidism. SLC26A4 is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters.
Background: Pendrin is an ion exchanger found in the cortical collecting duct.Pendrin is found at the luminal membrane of follicular cells in the thyroid gland. It transports iodine from the cytoplasm to the follicle lumen. Its activity is necessary for production of thyroid hormone.Pendrin is also found in the cells of the inner ear, where its function is not well understood. Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. Pendred syndrome is also characterized by hypothyroidism. SLC26A4 is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
pendrin
NCBI Official Synonym Full Names
solute carrier family 26 member 4
NCBI Official Symbol
SLC26A4
NCBI Official Synonym Symbols
EVA; PDS; DFNB4; TDH2B
NCBI Protein Information
pendrin
UniProt Protein Name
Pendrin
Protein Family
UniProt Gene Name
SLC26A4
UniProt Synonym Gene Names
PDS
NCBI Description
Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters. [provided by RefSeq, Jul 2008]
Uniprot Description
Sodium-independent transporter of chloride and iodide.
Research Articles on PDS
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Product Notes
The Human PDS slc26a4 (Catalog #AAA9714276) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9714276 ELISA Kit recognizes Human PDS. It is sometimes possible for the material contained within the vial of "Pendrin (SLC26A4), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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