Programmed Cell Death 5 Recombinant Protein | PDCD5 recombinant protein
Recombinant Human Programmed Cell Death 5
Gene Names
PDCD5; TFAR19
Purity
Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Synonyms
Programmed Cell Death 5; Recombinant Human Programmed Cell Death 5; PDCD5 Human; Programmed Cell Death-5 Human Recombinant; Programmed cell death protein 5; TF-1 cell apoptosis-related protein 19; Protein TFAR19; PDCD5; TFAR19; MGC9294; PDCD5 recombinant protein
Host
E Coli
Purity/Purification
Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Form/Format
PDCD5 protein solution contains 1x PBS pH-7.4.
Sterile Filtered colorless solution.
Sterile Filtered colorless solution.
Sequence
MADEELEALR RQRLAELQAK HGDPGDAAQQ EAKHRGAEMR NSILAQVLDQ SARARLSNLA LVKPEKTKAV ENYLIQMARY GQLSEKVSEQ GLIEILKKVS QQTEKTTTVK LNRRKVMDSD EDDDY
Sequence Length
125
Preparation and Storage
PDCD5 although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Related Product Information for PDCD5 recombinant protein
Description: PDCD5 Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 125 amino acids and having a molecular mass of 14 kDa.
Introduction: PDCD5 is expressed in tumor cells during apoptosis independent of the apoptosis-inducing stimuli. Prior to apoptosis induction, PDCD5 is distributed in both the nucleus and cytoplasm. Once apoptosis is induced, the amount of PDCD5 increases and by relocation from the cytoplasm, it accumulates in the nucleus.PDCD5 protein has a stable helical core conformation consisting of a triple-helix bundle and two dissociated terminal regions. PDCD5 is an important novel protein that regulates both apoptotic and non-apoptotic programmed cell death. PDCD5 functions in the process of apoptosis. Exogenous PDCD5 expression increases the chemosensitivity of K562 leukemia cells to low or high doses of idarubicin in vitro, resulting in increased apoptosis. PDCD5 plays an important role in regulation of apoptotic processes in gastric cancer cells and gastric tumors. PDCD5 plays a role in the pathogenesis of rheumatoid arthritis. -27G/-11A SNP is associated with reduced PDCD5 promoter activity and increased susceptibility to chronic myelogenous leukemia. PDCD5 gene may be a target gene under the control of some important apoptosis-related transcriptional factors during the cell apoptosis.
Introduction: PDCD5 is expressed in tumor cells during apoptosis independent of the apoptosis-inducing stimuli. Prior to apoptosis induction, PDCD5 is distributed in both the nucleus and cytoplasm. Once apoptosis is induced, the amount of PDCD5 increases and by relocation from the cytoplasm, it accumulates in the nucleus.PDCD5 protein has a stable helical core conformation consisting of a triple-helix bundle and two dissociated terminal regions. PDCD5 is an important novel protein that regulates both apoptotic and non-apoptotic programmed cell death. PDCD5 functions in the process of apoptosis. Exogenous PDCD5 expression increases the chemosensitivity of K562 leukemia cells to low or high doses of idarubicin in vitro, resulting in increased apoptosis. PDCD5 plays an important role in regulation of apoptotic processes in gastric cancer cells and gastric tumors. PDCD5 plays a role in the pathogenesis of rheumatoid arthritis. -27G/-11A SNP is associated with reduced PDCD5 promoter activity and increased susceptibility to chronic myelogenous leukemia. PDCD5 gene may be a target gene under the control of some important apoptosis-related transcriptional factors during the cell apoptosis.
Product Categories/Family for PDCD5 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
14,997 Da
NCBI Official Full Name
programmed cell death protein 5
NCBI Official Synonym Full Names
programmed cell death 5
NCBI Official Symbol
PDCD5
NCBI Official Synonym Symbols
TFAR19
NCBI Protein Information
programmed cell death protein 5; TF-1 cell apoptosis-related protein 19; TF1 cell apoptosis-related gene 19; TFAR19 novel apoptosis-related
UniProt Protein Name
Programmed cell death protein 5
Protein Family
UniProt Gene Name
PDCD5
UniProt Synonym Gene Names
TFAR19; Protein TFAR19
UniProt Entry Name
PDCD5_HUMAN
NCBI Description
This gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12 [provided by RefSeq, Dec 2010]
Uniprot Description
PDCD5: May function in the process of apoptosis. Belongs to the PDCD5 family.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 19q13.11
Cellular Component: cytoplasm; nucleus
Molecular Function: heparin binding; protein binding; DNA binding; beta-tubulin binding
Biological Process: negative regulation of cell proliferation; positive regulation of apoptosis; positive regulation of caspase activity
Research Articles on PDCD5
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Product Notes
The PDCD5 pdcd5 (Catalog #AAA143438) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MADEELEALR RQRLAELQAK HGDPGDAAQQ EAKHRGAEMR NSILAQVLDQ SARARLSNLA LVKPEKTKAV ENYLIQMARY GQLSEKVSEQ GLIEILKKVS QQTEKTTTVK LNRRKVMDSD EDDDY. It is sometimes possible for the material contained within the vial of "Programmed Cell Death 5, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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