Polycomb group RING finger protein 2 (Pcgf2) Recombinant Protein | Pcgf2 recombinant protein

Recombinant Mouse Polycomb group RING finger protein 2 (Pcgf2)

Cat. Num. AAA951873

• Gene Names: Pcgf2; Mel18; Rnf110; Zfp144; mel-18
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Polycomb group RING finger protein 2 (Pcgf2); Recombinant Mouse Polycomb group RING finger protein 2 (Pcgf2); Pcgf2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-342, Full length protein
• Sequence: MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPNGSNEDRGEVLEQEKGALGDDEIVSLSIEFYEGVRDREEKKNLTENGDGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEILYEDEPLKEYYTLMDIAYIYPWRRNGPLPLKYRVQPACKRLTLPTVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSSHGPPATHPTSPTPPSTAAGTTTATNGGTSNCLQTPSSTSRGRKMTVNGAPCPP
• Sequence Length: 342

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Pcgf2 recombinant protein

This protein contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.

NCBI and Uniprot Product Information

• NCBI GI #: 254028181
• NCBI GeneID: 22658
• NCBI Accession #: NP_001156779.1
• NCBI GenBank Nucleotide #: NM_001163307.1
• UniProt Accession #: P23798
• Molecular Weight: 37,723 Da
• NCBI Official Full Name: polycomb group RING finger protein 2
• NCBI Official Synonym Full Names: polycomb group ring finger 2
• NCBI Official Symbol: Pcgf2
• NCBI Official Synonym Symbols: Mel18; Rnf110; Zfp144; mel-18
• NCBI Protein Information: polycomb group RING finger protein 2
• UniProt Protein Name: Polycomb group RING finger protein 2
• Protein Family: Polycomb group RING finger protein
• UniProt Gene Name: Pcgf2
• UniProt Synonym Gene Names: Mel-18; Mel18; Rnf110; Zfp144; Znf144; Zfp-144

Uniprot Description

Transcriptional repressor (PubMed:8521824). Binds specifically to the DNA sequence 5'-GACTNGACT-3' (PubMed:8521824). Has tumor suppressor activity (PubMed:8521824). May play a role in control of cell proliferation and/or neural cell development (Probable). Regulates proliferation of early T progenitor cells by maintaining expression of HES1(PubMed:15728456). Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (PubMed:8625838, PubMed:15183898). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity ().