Mouse par-3 partitioning defective 3 homolog (C. elegans) ELISA Kit | PARD3 elisa kit
Mouse Partitioning defective 3 homolog, PARD3 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
PAR3-alpha: an adapter protein involved in asymmetrical cell division, and cell polarization processes. Polarity complex proteins, including PARD3, are essential for PIP3-induced receptor tyrosine kinase recycling. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Association with PARD6B may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons. PDZ 1 domain modulates interactions with JAM1, PARD6A and PARD6B; PDZ 2 domain mediates interaction with membranes containing phosphoinositol lipids; PDZ 3 domain regulates interactions with PTEN (via C-terminus). Belongs to the PAR3 family. 10 isoforms of the human protein are produced by alternative splicing. Isoform 2, but not at least isoform 3 interacts with PRKCZ.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Cellular Component: tight junction; protein complex; lateral loop; intercellular junction; cell cortex; internode region of axon; adherens junction; cytoskeleton; cell-cell adherens junction; membrane; cell soma; apical part of cell; cytoplasm; plasma membrane; spindle; intracellular; cell junction
Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; protein kinase C binding; lipid binding; protein phosphatase binding; phosphatidylinositol 3-phosphate binding
Biological Process: positive regulation of myelination; regulation of actin filament-based process; cell-cell adhesion; centrosome localization; cell division; establishment and/or maintenance of cell polarity; microtubule cytoskeleton organization and biogenesis; cell cycle; cell differentiation; protein targeting to membrane; myelination in the peripheral nervous system
Research Articles on PARD3
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Product Notes
The Mouse PARD3 pard3 (Catalog #AAA9330421) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9330421 ELISA Kit recognizes Mouse PARD3. It is sometimes possible for the material contained within the vial of "par-3 partitioning defective 3 homolog (C. elegans), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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