Poly (A) polymerase gamma (PAPOLG) Recombinant Protein | PAPOLG recombinant protein

Recombinant Human Poly (A) polymerase gamma (PAPOLG)

Cat. Num. AAA1466618

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Poly (A) polymerase gamma (PAPOLG); Recombinant Human Poly (A) polymerase gamma (PAPOLG); PAPOLG recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-736, Full length protein
• Sequence: MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHRLVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISDNLDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNMLGFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQSFPGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEGMKIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNGTPFNSPASKSDSPSVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSPPTVCTIPTVVGRNVIPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKDVEKFIRLESTFKDPRTAEERKRKSVDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR
• Sequence Length: 736

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for PAPOLG recombinant protein

This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3 end of a DNA
RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)
AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14.

NCBI and Uniprot Product Information

• NCBI GI #: 16306568
• NCBI GeneID: 64895
• NCBI Accession #: NP_075045.2
• NCBI GenBank Nucleotide #: NM_022894.3
• UniProt Accession #: Q9BWT3; Q59G05; Q969N1; Q9H8L2; Q9HAD0; B2RBH4
• Molecular Weight: 80,127 Da
• NCBI Official Full Name: poly(A) polymerase gamma
• NCBI Official Synonym Full Names: poly(A) polymerase gamma
• NCBI Official Symbol: PAPOLG
• NCBI Protein Information: poly(A) polymerase gamma
• UniProt Protein Name: Poly(A) polymerase gamma
• Protein Family: Poly(A) polymerase
• UniProt Gene Name: PAPOLG
• UniProt Synonym Gene Names: PAP2; PAPG; PAP-gamma; Neo-PAP; SRP RNA-adenylating enzyme

NCBI Description

This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14. [provided by RefSeq, Jul 2008]

Uniprot Description

Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA.