Adducin gamma Blocking Peptide | P452 blocking peptide

Adducin gamma (P452) Peptide

Cat. Num. AAA3002296

• Gene Names: ADD3; ADDL; CPSQ3
• Applications: Blocking
• Purity: Synthetic peptide Adducin gamma (P452). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: Adducin gamma; Adducin gamma (P452) Peptide; ADD3; ADDG; ADDL; Adducin 3 (gamma); Adducin 3; Adducin-like protein 70; Gamma-adducin; Adducingamma; P452 blocking peptide

• Specificity: This peptide can be used with studies using MBS3002295 Adducin gamma (P452) pAb.
• Purity/Purification: Synthetic peptide Adducin gamma (P452). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 674

• Applicable Applications for P452 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for P452 blocking peptide

Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta and gamma). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-actin junction of the membrane skeleton. The cortical actin cytoskeletal network is lost during apoptosis and adducins are central in the cortical actin network organization. Adducin alpha is a cytoskeletal protein involved with sodium-pump activity in the renal tubule and is associated with hypertension. The expression of Adducin alpha and Adducin gamma is ubiquitous in contrast to the restricted expression of Adducin beta. Adducin beta is expressed at high levels in brain andhematopoietic tissues, such as bone marrow in humans, and spleen in mice.

NCBI and Uniprot Product Information

• NCBI GI #: 62912453
• NCBI GeneID: 120
• NCBI Accession #: NP_001112.2
• NCBI GenBank Nucleotide #: NP_001112.2
• UniProt Accession #: Q9UEY8
• NCBI Official Full Name: gamma-adducin isoform b
• NCBI Official Synonym Full Names: adducin 3
• NCBI Official Symbol: ADD3
• NCBI Official Synonym Symbols: ADDL; CPSQ3
• NCBI Protein Information: gamma-adducin
• UniProt Protein Name: Gamma-adducin
• UniProt Gene Name: ADD3
• UniProt Synonym Gene Names: ADDL
• UniProt Entry Name: ADDG_HUMAN

NCBI Description

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]

Uniprot Description

ADD3: is a heteromeric protein composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. Adducins alpha and gamma are ubiquitously expressed, while the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions of alpha and beta have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 10q25.2

Cellular Component: nucleoplasm; cytoskeleton; condensed nuclear chromosome; membrane; cytoplasm; plasma membrane; intercellular junction; cell cortex

Molecular Function: calmodulin binding; structural constituent of cytoskeleton; actin binding