Human Oncostatin-M-specific receptor subunit beta ELISA Kit | OSMR elisa kit

Human Oncostatin-M-specific receptor subunit beta ELISA Kit

Cat. Num. AAA763484

• Gene Names: OSMR; OSMRB; PLCA1
• Reactivity: Human
• Synonyms: Oncostatin-M-specific receptor subunit beta; Human Oncostatin-M-specific receptor subunit beta ELISA Kit; OSMR (Oncostatin M Receptor)/OSMRB/IL-31 receptor subunit beta/IL-31R subunit beta/IL-31R-beta/IL-31RB/Interleukin-31 receptor subunit beta/Oncostatin-M-specific receptor subunit beta; OSMR elisa kit

• Reactivity: Human
• Sequence Length: 979

• Samples: Serum, plasma and other biological fluids.
• Assay Type: Sandwich ELISA, Double Antibody
• Detection Range: 0.156-10ng/ml
• Sensitivity: 0.094ng/ml
• Preparation and Storage: Store at 4 degree C if kit is to be used within 1 week. Stable for 6 months (if micro ELISA Plate, Lyophilized Standard and Concentrated Biotinylated Detection Protein stored at-20 degree C. Other components at 2-8 degree C). Stable for 12 months (if the entire kit is stored at-20 degree C).

Typical Testing Data

Typical Standard Curve

Related Product Information for OSMR elisa kit

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti-OSMR antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-OSMR antibody was used as detection antibodies. The standards, test samples and biotin conjugated detection antibody were added to the wells subsequently, and wash with wash buffer. HRP-Streptavidin was added and unbound conjugates were washed away with wash buffer. TMB substrates were used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the OSMR amount of sample captured in plate. Read the O.D. absorbance at 450nm in a microplate reader, and then the concentration of OSMR can be calculated.

NCBI and Uniprot Product Information

• NCBI GI #: 4557040
• NCBI GeneID: 9180
• NCBI Accession #: NP_003990.1
• NCBI GenBank Nucleotide #: NM_003999.2
• Molecular Weight: 39,504 Da
• NCBI Official Full Name: oncostatin-M-specific receptor subunit beta isoform 1
• NCBI Official Synonym Full Names: oncostatin M receptor
• NCBI Official Symbol: OSMR
• NCBI Official Synonym Symbols: OSMRB; PLCA1
• NCBI Protein Information: oncostatin-M-specific receptor subunit beta
• UniProt Protein Name: Oncostatin-M-specific receptor subunit beta
• Protein Family: Oncostatin-M-specific receptor
• UniProt Gene Name: OSMR
• UniProt Synonym Gene Names: OSMRB; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB
• UniProt Entry Name: OSMR_HUMAN

NCBI Description

This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Uniprot Description

OSMR: Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. Defects in OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1); also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Belongs to the type I cytokine receptor family. Type 2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: apical plasma membrane; external side of plasma membrane; oncostatin-M receptor complex; plasma membrane

Molecular Function: cytokine binding; growth factor binding; oncostatin-M receptor activity

Biological Process: positive regulation of acute inflammatory response; positive regulation of cell proliferation; response to cytokine stimulus

Disease: Amyloidosis, Primary Localized Cutaneous, 1