Ornithine decarboxylase antizyme 2 (OAZ2) Recombinant Protein | OAZ2 recombinant protein

Recombinant Human Ornithine decarboxylase antizyme 2 (OAZ2)

Cat. Num. AAA1238832

• Gene Names: OAZ2; AZ2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ornithine decarboxylase antizyme 2 (OAZ2); Recombinant Human Ornithine decarboxylase antizyme 2 (OAZ2); OAZ2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-189, Full length protein
• Sequence: MINTQDSSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSLSALIYKDEKLTVTQDLPVNDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFVEIPDGLLADGSKEGLLALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYPLDQNLSDED
• Sequence Length: 189

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for OAZ2 recombinant protein

Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase but does not accelerate its degradation.

NCBI and Uniprot Product Information

• NCBI GI #: 9845507
• NCBI GeneID: 4947
• NCBI Accession #: NP_002528.1
• NCBI GenBank Nucleotide #: NM_002537.3
• UniProt Accession #: O95190
• Molecular Weight: 21,011 Da
• NCBI Official Full Name: ornithine decarboxylase antizyme 2 isoform 1
• NCBI Official Synonym Full Names: ornithine decarboxylase antizyme 2
• NCBI Official Symbol: OAZ2
• NCBI Official Synonym Symbols: AZ2
• NCBI Protein Information: ornithine decarboxylase antizyme 2
• UniProt Protein Name: Ornithine decarboxylase antizyme 2
• Protein Family: Ornithine decarboxylase antizyme
• UniProt Gene Name: OAZ2
• UniProt Synonym Gene Names: AZ2; ODC-Az 2

NCBI Description

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamines. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]

Uniprot Description

Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol ().