HNT/NTM Recombinant Protein | NTM recombinant protein

HNT/NTM Protein, Human, Recombinant (hFc Tag)

Cat. Num. AAA8121821

• Gene Names: NTM; HNT; NTRI; IGLON2
• Purity: >95% as determined by SDS-PAGE
• Synonyms: HNT/NTM; HNT/NTM Protein; Human; Recombinant (hFc Tag); Human NTM/Neurotrimin Protein (Fc Tag); HNT Protein; IGLON2 Protein; NTRI Protein; neurotrimin; NTM recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Gly312

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Gly 34
• Tag: C-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the human NTM (NP_057606.1)(Met1-Gly312) was expressed with the Fc region of human IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for NTM recombinant protein

Background: NTM (Neurotrimin) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. IgLONs have been associated with psychiatric disorders, intelligence, body weight, heart disease, and tumors. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. Neurotrimin is a member of the family of neural cell adhesion molecules. Its expression pattern suggests that Ntm promotes axonal fasciculation, guides nerve fibers to specific targets and stabilizes synapses as it accumulates coincident with synaptogenesis. Diseases associated with NTM include Connective Tissue Disease and Jacobsen Syndrome.

NCBI and Uniprot Product Information

• NCBI GI #: 7705413
• NCBI GeneID: 50863
• NCBI Accession #: NP_057606.1
• NCBI GenBank Nucleotide #: NM_016522.2
• UniProt Accession #: Q9P121; Q6UXJ3; Q86VJ9; A0MTT2
• Molecular Weight: 39,227 Da
• NCBI Official Full Name: neurotrimin isoform 1
• NCBI Official Synonym Full Names: neurotrimin
• NCBI Official Symbol: NTM
• NCBI Official Synonym Symbols: HNT; NTRI; IGLON2
• NCBI Protein Information: neurotrimin; IgLON family member 2
• UniProt Protein Name: Neurotrimin
• Protein Family: Neurotrimin
• UniProt Gene Name: NTM
• UniProt Synonym Gene Names: IGLON2; NT; hNT
• UniProt Entry Name: NTRI_HUMAN

NCBI Description

This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML), on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

Uniprot Description

NT: Neural cell adhesion molecule. Belongs to the immunoglobulin superfamily. IgLON family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 11q25

Cellular Component: neuron projection; cell surface; cell soma; plasma membrane; intercellular junction

Molecular Function: protein binding

Biological Process: cell-cell adhesion; regulation of neurogenesis; neuron recognition; cell adhesion