Pro-neuregulin-3 Recombinant Protein | NRG3 recombinant protein

Recombinant Human Pro-neuregulin-3, membrane-bound isoform

Cat. Num. AAA718407

• Gene Names: NRG3; HRG3; pro-NRG3
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Pro-neuregulin-3; Recombinant Human Pro-neuregulin-3; membrane-bound isoform; Pro-NRG3; NRG3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-360. Partial, provide theExtracellular Domain
• Sequence: MSEGAAAASPPGAASAAAASAEEGTAAAAAAAAAGGGPDGGGEGAAEPPRELRCSDCIVWNRQQTWLCVVPLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDLVDSKGMGQDPFFLSKPSSFPKAMETTTTTTSTTSPATPSAGGAASSRTPNRISTRLTTITRAPTRFPGHRVPIRASPRSTTARNTAAPATVPSTTAPFFSSSTLGSRPPVPGTPSTQAMPSWPTAAYATSSYLHDSTPSWTLSPFQDAASSSSSSSSSATTTTPETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEEVYQRQ
• Sequence Length: 360

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for NRG3 recombinant protein

Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes

Product Categories/Family for NRG3 recombinant protein

Cancer

References

"Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4." Zhang D., Sliwkowski M.X., Mark M., Frantz G., Akita R., Sun Y., Hillan K., Crowley C., Brush J., Godowski P.J. Proc. Natl. Acad. Sci. U.S.A. 94:9562-9567(1997)

NCBI and Uniprot Product Information

• NCBI GI #: 66730481
• NCBI GeneID: 10718
• NCBI Accession #: NP_001010848.2
• NCBI GenBank Nucleotide #: NM_001010848.3
• UniProt Accession #: P56975; Q0PEH2; Q5VYH3; A4D7U1
• Molecular Weight: 53.8 kDa
• NCBI Official Synonym Full Names: neuregulin 3
• NCBI Official Symbol: NRG3
• NCBI Official Synonym Symbols: HRG3; pro-NRG3
• NCBI Protein Information: pro-neuregulin-3, membrane-bound isoform
• UniProt Protein Name: Pro-neuregulin-3, membrane-bound isoform
• Protein Family: Pro-neuregulin
• UniProt Gene Name: NRG3
• UniProt Synonym Gene Names: Pro-NRG3; NRG-3
• UniProt Entry Name: NRG3_HUMAN

NCBI Description

This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]

Uniprot Description

NRG3: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. Belongs to the neuregulin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinase

Chromosomal Location of Human Ortholog: 10q23.1

Cellular Component: extracellular region; extracellular space; integral to plasma membrane; intracellular

Molecular Function: chemorepellent activity; growth factor activity; receptor binding; receptor tyrosine kinase binding; transmembrane receptor protein tyrosine kinase activator activity

Biological Process: chemorepulsion involved in interneuron migration from the subpallium to the cortex; organ development; pattern specification process; regulation of cell growth; transmembrane receptor protein tyrosine kinase activation (dimerization)