Glucocorticoid Receptor Alpha (GRa) Recombinant Protein | GRa recombinant protein
Recombinant Glucocorticoid Receptor Alpha (GRa)
MGHHHHHHSGS-ASGNLLCFA PDLIINEQRM TLPCMYDQCK HMLFISTELQ RLQVSYEEYL CMKTLLLLSS VPKEGLKSQE LFDEIRMTYI KELGKAIVKR EGNSSQNWQR FYQLTKLLDS MHDVVENLLS YCFQTFLDKS MSIEF
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
NCBI and Uniprot Product Information
Uniprot Description
GR: transcription factor of the nuclear receptor family. Receptor for glucocorticoids (GC). Binds to glucocorticoid response elements (GRE) and modulates other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Three alternatively spliced isoforms have been described.
Protein type: Nuclear receptor; Mitochondrial; DNA-binding; Transcription factor
Cellular Component: nucleoplasm; neuron projection; protein complex; mitochondrion; membrane; postsynaptic density; cytoplasm; dendritic spine; intracellular; cytosol; nucleus
Molecular Function: protein dimerization activity; protein homodimerization activity; hormone binding; zinc ion binding; metal ion binding; transcription coactivator activity; Hsp70 protein binding; Hsp90 protein binding; receptor tyrosine kinase binding; transcription factor binding; steroid binding; glucocorticoid receptor activity; protein binding; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; heat shock protein binding; double-stranded DNA binding; protein complex binding; steroid hormone receptor activity; chromatin binding; transcription factor activity; lipid binding
Biological Process: transcription from RNA polymerase II promoter; negative regulation of synaptic plasticity; transcription, DNA-dependent; maternal behavior; adrenal gland development; response to arsenic; positive regulation of glutamate secretion; regulation of glucocorticoid biosynthetic process; chromatin modification; regulation of cell proliferation; chromatin remodeling; glucocorticoid metabolic process; glucocorticoid mediated signaling; regulation of transcription, DNA-dependent; chromatin-mediated maintenance of transcription; glucocorticoid receptor signaling pathway; positive regulation of neuron apoptosis; negative regulation of vascular permeability; regulation of gluconeogenesis; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter
Research Articles on GRa
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Product Notes
The GRa nr3c1 (Catalog #AAA2009609) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Glucocorticoid Receptor Alpha (GRa) can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the GRa nr3c1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: The target protein is fused with N-terminal His-Tag, its sequence is listed below. MGHHHHHHSG S-ASGNLLCF A PDLIINEQRM TLPCMYDQCK HMLFISTELQ RLQVSYEEYL CMKTLLLLSS VPKEGLKSQE LFDEIRMTYI KELGKAIVKR EGNSSQNWQR FYQLTKLLDS MHDVVENLLS YCFQTFLDKS MSIEF. It is sometimes possible for the material contained within the vial of "Glucocorticoid Receptor Alpha (GRa), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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