NPRC/NPR3 recombinant protein

Recombinant Human NPRC/NPR3 (C-Fc)

Cat. Num. AAA2569205

• Gene Names: NPR3; NPRC; ANP-C; ANPRC; NPR-C; ANPR-C; GUCY2B; C5orf23
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: NPRC/NPR3; Recombinant Human NPRC/NPR3 (C-Fc); ANP-C; ANPR-C; NPR3; NPRC; NPR-C; ANPRC; C5orf23; NPRC/NPR3 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
• Sequence: Thr24-Glu481

• Species: Human
• Tag: C-Fc
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Human Atrial Natriuretic Peptide Receptor 3 is produced by our Mammalian expression system and the target gene encoding Thr24-Glu481 is expressed with a Fc tag at the C-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for NPRC/NPR3 recombinant protein

Atrial Natriuretic Peptide Receptor-3 (NPR3), also known as NPRC or ANPR-C, is one of the three natriuretic peptide receptors, is a type I transmembrane glycoprotein. The natriuretic system is key to the maintenance of vascular tone and cardiovascular homeostasis. Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Osteocrin was found to be a specific ligand to NPR3. NPR3 is necessary for Osteocrin to regulate femoral, tibial, and metatarsal bone elongation.

Product Categories/Family for NPRC/NPR3 recombinant protein

Signal Transduction; Cardiovascular

NCBI and Uniprot Product Information

• NCBI GI #: 324120923
• NCBI GeneID: 4883
• NCBI Accession #: NP_001191305.1
• NCBI GenBank Nucleotide #: NM_001204376.1
• UniProt Accession #: P17342; A2RRD1; B4DT84; E7EPG9
• Molecular Weight: 59,767 Da
• NCBI Official Full Name: atrial natriuretic peptide receptor 3 isoform 3
• NCBI Official Synonym Full Names: natriuretic peptide receptor 3
• NCBI Official Symbol: NPR3
• NCBI Official Synonym Symbols: NPRC; ANP-C; ANPRC; NPR-C; ANPR-C; GUCY2B; C5orf23
• NCBI Protein Information: atrial natriuretic peptide receptor 3
• UniProt Protein Name: Atrial natriuretic peptide receptor 3
• UniProt Gene Name: NPR3
• UniProt Synonym Gene Names: ANPRC; C5orf23; NPRC; ANP-C; ANPR-C; NPR-C

NCBI Description

This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

Uniprot Description

Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.