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Nucleophosmin (NPM) Recombinant Protein | NPM recombinant protein
Recombinant Nucleophosmin (NPM)
MGHHHHHHSGSEF- DLKPSTPRS KGQESFKKQE KTPKTPKGPS SVEDIKAKMQ ASIEKGGSLP KVEAKFINYV KNCFRMTDQE AIQDLWQWRK SL
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
SDS-Page
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NCBI and Uniprot Product Information
Uniprot Description
NPM1: a nucleolar protein associated with nucleolar ribonucleoprotein structures and that binds single-stranded nucleic acids. Is a major component of template activating factor (TAF)-III. It plays a role in controlling centrosome duplication, and may function in the assembly and/or transport of the ribosome. Two alternatively spliced isoforms have been described.
Protein type: RNA-binding; Nucleolus; Oncoprotein; Translation
Cellular Component: centrosome; small ribosomal subunit; granular component; focal adhesion; cell; spindle pole centrosome; cytosol; ribonucleoprotein complex; nucleoplasm; cytoskeleton; membrane; cytoplasm; nucleolus; nuclear speck; intracellular; nucleus; large ribosomal subunit
Molecular Function: protein homodimerization activity; protein kinase inhibitor activity; histone binding; RNA binding; transcription coactivator activity; unfolded protein binding; protein kinase binding; ribosomal large subunit binding; NF-kappaB binding; rRNA binding; protein binding; enzyme binding; phosphatidylinositol-3,4,5-triphosphate binding; nucleic acid binding; DNA binding; Tat protein binding; protein heterodimerization activity; ribosomal small subunit binding
Biological Process: positive regulation of catalytic activity; positive regulation of DNA metabolic process; regulation of centriole replication; positive regulation of translation; regulation of cell cycle; centrosome cycle; nucleocytoplasmic transport; ribosomal large subunit biogenesis and assembly; ribosomal large subunit export from nucleus; regulation of DNA damage response, signal transduction by p53 class mediator; activation of NF-kappaB transcription factor; negative regulation of cell proliferation; protein localization; regulation of neuron apoptosis; positive regulation of cell proliferation; response to stress; cell growth; protein homooligomerization; ribosomal small subunit export from nucleus; protein destabilization; cell aging; positive regulation of cellular biosynthetic process; DNA repair; protein oligomerization; ribosomal small subunit biogenesis and assembly; nucleosome assembly; regulation of endodeoxyribonuclease activity; rRNA export from nucleus; negative regulation of nuclear mRNA splicing, via spliceosome; positive regulation of protein kinase activity; cell volume homeostasis; positive regulation of DNA replication; negative regulation of apoptosis
Research Articles on NPM
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Product Notes
The NPM npm1 (Catalog #AAA2011672) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Nucleophosmin (NPM) can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the NPM npm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: The target protein is fused with N-terminal His-Tag, its sequence is listed below. MGHHHHHHSG SEF- DLKPSTPRS KGQESFKKQE KTPKTPKGPS SVEDIKAKMQ ASIEKGGSLP KVEAKFINYV KNCFRMTDQE AIQDLWQWRK SL. It is sometimes possible for the material contained within the vial of "Nucleophosmin (NPM), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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