PSA Blocking Peptide | NPEPPS blocking peptide

PSA Antibody (C-term) Blocking Peptide

• Gene Names: NPEPPS; PSA; AAP-S; MP100
• Synonyms: PSA; PSA Antibody (C-term) Blocking Peptide; Puromycin-sensitive aminopeptidase; Cytosol alanyl aminopeptidase; AAP-S; NPEPPS; NPEPPS blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human PSA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 919

• Cellular Location: Cytoplasm, cytosol. Nucleus
• Tissue Location: Detected in liver, epithelium of renal tubules, epithelium of small and large intestine, gastric epithelial cells, and alveoli of the lung (at protein level)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NPEPPS blocking peptide

Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.

NCBI and Uniprot Product Information

• NCBI GI #: 51704228
• NCBI GeneID: 9520
• UniProt Accession #: P55786; Q6P145; Q9NP16; Q9UEM2; B7Z463
• Molecular Weight: 94,516 Da
• NCBI Official Full Name: Puromycin-sensitive aminopeptidase
• NCBI Official Synonym Full Names: aminopeptidase puromycin sensitive
• NCBI Official Symbol: NPEPPS
• NCBI Official Synonym Symbols: PSA; AAP-S; MP100
• NCBI Protein Information: puromycin-sensitive aminopeptidase
• UniProt Protein Name: Puromycin-sensitive aminopeptidase
• Protein Family: PsaJ-like protein asl3190
• UniProt Gene Name: NPEPPS
• UniProt Synonym Gene Names: PSA; PSA; AAP-S
• UniProt Entry Name: PSA_HUMAN

NCBI Description

This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008]

Uniprot Description

NPEPPS: Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. Belongs to the peptidase M1 family.

Protein type: Protease; EC 3.4.11.14

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: cytosol; plasma membrane

Molecular Function: aminopeptidase activity; peptide binding; zinc ion binding

Biological Process: peptide catabolic process; protein polyubiquitination