NOSTRIN recombinant protein

Recombinant Human NOSTRIN protein

Cat. Num. AAA1562632

• Gene Names: NOSTRIN; DaIP2
• Purity: >90% as determined by SDS-PAGE
• Synonyms: NOSTRIN; Recombinant Human NOSTRIN protein; Nostrin; BM247 homolog; Nitric oxide synthase traffic inducer; Nitric oxide synthase trafficker; eNOS-trafficking inducer; NOSTRIN recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human NOSTRIN (Met79-Ala251) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for NOSTRIN recombinant protein

Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.

Product Categories/Family for NOSTRIN recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 284172483
• NCBI GeneID: 115677
• NCBI Accession #: NP_001165103.1
• NCBI GenBank Nucleotide #: NM_001171632.1
• UniProt Accession #: Q8IVI9; Q27HG3; Q53S62; Q96CJ9; A8K2I9; B3KSF5; E7EPT9
• Molecular Weight: 57,660 Da
• NCBI Official Full Name: nostrin isoform 3
• NCBI Official Synonym Full Names: nitric oxide synthase trafficking
• NCBI Official Symbol: NOSTRIN
• NCBI Official Synonym Symbols: DaIP2
• NCBI Protein Information: nostrin; BM247 homolog; ENOS traffic inducer; eNOS-trafficking inducer; nitric oxide synthase trafficker; nitric oxide synthase traffic inducer; endothelial nitric oxide synthase traffic inducer; ortholog of mouse disabled 2 interacting proein 2
• UniProt Protein Name: Nostrin
• Protein Family: Nostrin
• UniProt Gene Name: NOSTRIN
• UniProt Entry Name: NOSTN_HUMAN

NCBI Description

Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004]

Uniprot Description

NOSTRIN: Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: cytoskeleton; plasma membrane; nucleus

Molecular Function: protein binding; DNA binding

Biological Process: endocytosis; regulation of nitric-oxide synthase activity; signal transduction; negative regulation of transcription, DNA-dependent; nitric oxide metabolic process