Human NLR family, pyrin domain containing 11 ELISA Kit | NLRP11 elisa kit
Human NACHT, LRR and PYD domains-containing protein 11, NLRP11 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]
Uniprot Description
NLRP11: Involved in inflammation (Potential). Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 19q13.43
Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen; ATP binding
Research Articles on NLRP11
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Product Notes
The Human NLRP11 nlrp11 (Catalog #AAA9342979) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9342979 ELISA Kit recognizes Human NLRP11. It is sometimes possible for the material contained within the vial of "NLR family, pyrin domain containing 11, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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