Human Nipped-B-like protein ELISA Kit | NIPBL elisa kit
Human Nipped-B-like protein (NIPBL) ELISA Kit
Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Inter-assay Precision (Precision between assays)
Three samples of known concentration were tested in forty separate assays to assess inter-assay precision.
CV (%) = SD/meanX100
Intra-Assay: CV
Inter-Assay: CV
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
NIPBL: a chromatin protein involved in sister chromatid cohesion. Interacts directly with CBX5 via the PxVxL motif, which is required for interaction with chromoshadow domains. Defects in NIPBL are the cause of Cornelia de Lange syndrome (CDL). CDL is a dominantly inherited multisystem developmental disorder. Three alternatively spliced isoforms have been reported.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 5p13.2
Cellular Component: chromatin; extracellular exosome; integrator complex; nucleoplasm; nucleus
Molecular Function: chromatin binding; chromo shadow domain binding; histone deacetylase binding; protein binding; protein C-terminus binding; protein N-terminus binding
Biological Process: brain development; cellular protein localization; cellular response to DNA damage stimulus; cellular response to X-ray; cognition; cohesin loading; developmental growth; ear morphogenesis; embryonic digestive tract morphogenesis; embryonic forelimb morphogenesis; embryonic viscerocranium morphogenesis; external genitalia morphogenesis; eye morphogenesis; fat cell differentiation; forelimb morphogenesis; heart morphogenesis; maintenance of mitotic sister chromatid cohesion; metanephros development; mitotic sister chromatid cohesion; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; outflow tract morphogenesis; positive regulation of histone deacetylation; positive regulation of multicellular organism growth; positive regulation of neuron migration; positive regulation of ossification; positive regulation of transcription from RNA polymerase II promoter; regulation of developmental growth; regulation of embryonic development; regulation of hair cycle; sensory perception of sound; stem cell maintenance; transcription, DNA-dependent
Disease: Cornelia De Lange Syndrome 1
Research Articles on NIPBL
Similar Products
Product Notes
The Human NIPBL nipbl (Catalog #AAA283915) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA283915 ELISA Kit recognizes Human NIPBL. It is sometimes possible for the material contained within the vial of "Nipped-B-like protein, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
