NIPA4 Blocking Peptide | NIPAL4 blocking peptide

NIPA4 Antibody (N-term) Blocking peptide

• Gene Names: NIPAL4; ARCI6; ICHYN; ICHTHYIN
• Synonyms: NIPA4; NIPA4 Antibody (N-term) Blocking peptide; Magnesium transporter NIPA4; Ichthyin; NIPA-like protein 4; Non-imprinted in Prader-Willi/Angelman syndrome region protein 4; NIPAL4; ICHN; NIPAL4 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 466

• Cellular Location: Membrane; Multi-pass membrane protein
• Tissue Location: Highly expressed in brain, lung, stomach, keratinocytes and leukocytes, and in all other tissues tested except liver, thyroid and fetal brain
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NIPAL4 blocking peptide

Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 149944536
• NCBI GeneID: 348938
• NCBI Accession #: NP_001092757.1
• NCBI GenBank Nucleotide #: NM_001099287.1
• UniProt Accession #: Q0D2K0; Q0D2J8; Q0D2J9; A8S6F1; A8S6F5; A8S6F8; B4DLF3
• Molecular Weight: 47,909 Da
• NCBI Official Full Name: magnesium transporter NIPA4 isoform 1
• NCBI Official Synonym Full Names: NIPA like domain containing 4
• NCBI Official Symbol: NIPAL4
• NCBI Official Synonym Symbols: ARCI6; ICHYN; ICHTHYIN
• NCBI Protein Information: magnesium transporter NIPA4
• UniProt Protein Name: Magnesium transporter NIPA4
• Protein Family: Magnesium transporter
• UniProt Gene Name: NIPAL4
• UniProt Synonym Gene Names: ICHN; NIPA4
• UniProt Entry Name: NIPA4_HUMAN

NCBI Description

This gene likely encodes a membrane receptor. Mutations in this gene have been associated with autosomal recessive congenital ichthyosis. [provided by RefSeq, Feb 2010]

Uniprot Description

ICHN: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway. Defects in NIPAL4 are the cause of ichthyosis congenital autosomal recessive ichthyin-related (ARCII). ARCII is a disorder of keratinization with abnormal differentiation and desquamation of the epidermis. The phenotype usually presents as non-bullous congenital ichthyosiform erythroderma (NCIE) with fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. Some of the families may show a more lamellar phenotype (lamellar ichthyosis). Belongs to the NIPA family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q33.3

Cellular Component: cytoplasm; nucleoplasm

Disease: Ichthyosis, Congenital, Autosomal Recessive 6