Rat NF-kappa-B inhibitor alpha ELISA Kit | Nfkbia elisa kit

Rat NF-kappa-B inhibitor alpha ELISA Kit

Cat. Num. AAA9427845

• Gene Names: Nfkbia; RL/IF-1
• Reactivity: Rat
• Synonyms: NF-kappa-B inhibitor alpha; Rat NF-kappa-B inhibitor alpha ELISA Kit; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; RL/IF-1; Nfkbia; Ikba; Nfkbia elisa kit

• Reactivity: Rat

• Samples: Serum, plasma, tissue homogenates and other biological fluids.
• Detection Range: 0.156-10 ng/mL
• Assay Time: 3-5h
• Sample Volume: 100T
• Detection Wavelength: 450 nm
• Preparation and Storage: Store at 4 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 160333919
• NCBI GeneID: 25493
• NCBI Accession #: NP_001099190.2
• NCBI GenBank Nucleotide #: NM_001105720.2
• UniProt Accession #: Q63746; B2RYS5
• Molecular Weight: 35,017 Da
• NCBI Official Full Name: NF-kappa-B inhibitor alpha
• NCBI Official Synonym Full Names: NFKB inhibitor alpha
• NCBI Official Symbol: Nfkbia
• NCBI Official Synonym Symbols: RL/IF-1
• NCBI Protein Information: NF-kappa-B inhibitor alpha
• UniProt Protein Name: NF-kappa-B inhibitor alpha
• Protein Family: NF-kappa-B inhibitor
• UniProt Gene Name: Nfkbia
• UniProt Synonym Gene Names: Ikba; IkB-alpha; IkappaBalpha

NCBI Description

inhibitor of NF-kappa-B; binds NF kappa B and retains it in the cytoplasm [RGD, Feb 2006]

Uniprot Description

IkB-alpha: a regulatory protein that inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation.

Protein type: DNA-binding; Inhibitor

Chromosomal Location of Human Ortholog: 6q23

Cellular Component: cytoplasm; cytosol; intracellular; nucleus; plasma membrane; protein complex

Molecular Function: enzyme binding; heat shock protein binding; identical protein binding; NF-kappaB binding; nuclear localization sequence binding; protein complex binding; ubiquitin protein ligase binding

Biological Process: cytoplasmic sequestering of NF-kappaB; cytoplasmic sequestering of transcription factor; I-kappaB kinase/NF-kappaB cascade; inhibition of NF-kappaB transcription factor; lipopolysaccharide-mediated signaling pathway; negative regulation of myeloid cell differentiation; negative regulation of Notch signaling pathway; positive regulation of cellular protein metabolic process; positive regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein import into nucleus, translocation; regulation of cell proliferation; regulation of gene expression; response to exogenous dsRNA; response to lipopolysaccharide; response to muramyl dipeptide; toll-like receptor 4 signaling pathway; tumor necrosis factor-mediated signaling pathway