Mouse Nuclear factor NF-kappa-B p105 subunit ELISA Kit | Nfkb1 elisa kit

Mouse Nuclear factor NF-kappa-B p105 subunit ELISA Kit

Cat. Num. AAA9427827

• Gene Names: Nfkb1; p50; p105; NF-KB1; p50/p105; NF-kappaB; NF-kappaB1
• Reactivity: Mouse
• Synonyms: Nuclear factor NF-kappa-B p105 subunit; Mouse Nuclear factor NF-kappa-B p105 subunit ELISA Kit; DNA-binding factor KBF1; EBP-1; NF-kappa-B1 p84/NF-kappa-B1 p98; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; Nfkb1; Nfkb1 elisa kit

• Reactivity: Mouse

• Samples: Serum, plasma, tissue homogenates and other biological fluids.
• Detection Range: 0.156-10 ng/mL
• Assay Time: 3-5h
• Sample Volume: 100T
• Detection Wavelength: 450 nm
• Preparation and Storage: Store at 4 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 117606364
• NCBI GeneID: 18033
• NCBI Accession #: NP_032715.2
• NCBI GenBank Nucleotide #: NM_008689.2
• UniProt Accession #: P25799; Q3TZE8; Q3V2V6; Q6TDG8; Q75ZL1; Q80Y21; Q8C712; B2RRQ6
• Molecular Weight: 43,983 Da
• NCBI Official Full Name: nuclear factor NF-kappa-B p105 subunit
• NCBI Official Synonym Full Names: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
• NCBI Official Symbol: Nfkb1
• NCBI Official Synonym Symbols: p50; p105; NF-KB1; p50/p105; NF-kappaB; NF-kappaB1
• NCBI Protein Information: nuclear factor NF-kappa-B p105 subunit
• UniProt Protein Name: Nuclear factor NF-kappa-B p105 subunit
• Protein Family: Nuclear factor
• UniProt Gene Name: Nfkb1

Uniprot Description

NFkB-p105: a transcription factor of the nuclear factor-kappaB ( NFkB) group. Undergoes cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of NFkB. NFkB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFkB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFkB has been associated with a number of inflammatory diseases while persistent inhibition of NFkB leads to inappropriate immune cell development or delayed cell growth. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. Two alternatively spliced isoforms have been described.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 3 G3|3 62.82 cM

Cellular Component: cytoplasm; cytosol; mitochondrion; neuron projection; nucleoplasm; nucleus; protein complex

Molecular Function: actinin binding; chromatin binding; DNA binding; double-stranded DNA binding; heat shock protein binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; innate immune response; lymph node development; negative regulation of apoptosis; negative regulation of cytokine production; negative regulation of inflammatory response; negative regulation of interleukin-12 biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; response to cytokine stimulus; response to organic cyclic substance; response to oxidative stress