Nuclear factor interleukin-3-regulated protein (NFIL3) Recombinant Protein | NFIL3 recombinant protein

Recombinant Human Nuclear factor interleukin-3-regulated protein (NFIL3)

Cat. Num. AAA1486469

• Gene Names: NFIL3; E4BP4; IL3BP1; NFIL3A; NF-IL3A
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Nuclear factor interleukin-3-regulated protein (NFIL3); Recombinant Human Nuclear factor interleukin-3-regulated protein (NFIL3); NFIL3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-462, Full length protein
• Sequence: MQLRKMQTVKKEQASLDASSNVDKMMVLNSALTEVSEDSTTGEELLLSEGSVGKNKSSACRRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDLVLENKLIALGEENATLKAELLSLKLKFGLISSTAYAQEIQKLSNSTAVYFQDYQTSKSNVSSFVDEHEPSMVSSSCISVIKHSPQSSLSDVSEVSSVEHTQESSVQGSCRSPENKFQIIKQEPMELESYTREPRDDRGSYTASIYQNYMGNSFSGYSHSPPLLQVNRSSSNSPRTSETDDGVVGKSSDGEDEQQVPKGPIHSPVELKHVHATVVKVPEVNSSALPHKLRIKAKAMQIKVEAFDNEFEATQKLSSPIDMTSKRHFELEKHSAPSMVHSSLTPFSVQVTNIQDWSLKSEHWHQKELSGKTQNSFKTGVVEMKDSGYKVSDPENLYLKQGIANLSAEVVSLKRLIATQPISASDSG
• Sequence Length: 462

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 585291057
• NCBI GeneID: 4783
• NCBI Accession #: NP_001276928.1
• NCBI GenBank Nucleotide #: NM_001289999.1
• UniProt Accession #: Q16649; Q14211; Q6FGQ8; Q96HS0; B2R9Y8
• Molecular Weight: 51,472 Da
• NCBI Official Full Name: nuclear factor interleukin-3-regulated protein
• NCBI Official Synonym Full Names: nuclear factor, interleukin 3 regulated
• NCBI Official Symbol: NFIL3
• NCBI Official Synonym Symbols: E4BP4; IL3BP1; NFIL3A; NF-IL3A
• NCBI Protein Information: nuclear factor interleukin-3-regulated protein
• UniProt Protein Name: Nuclear factor interleukin-3-regulated protein
• Protein Family: Nuclear factor interleukin-3-regulated protein
• UniProt Gene Name: NFIL3
• UniProt Synonym Gene Names: E4BP4; IL3BP1

NCBI Description

The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]

Uniprot Description

Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (). Represses transcriptional activity of PER1 (). Represses transcriptional activity of PER2 via the B-site on the promoter (). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (). Protects pro-B cells from programmed cell death ().