Rat neurofibromin 2 (merlin) ELISA Kit | NF2 elisa kit
Rat Merlin, NF2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
has similarity to a protein family involved in linking cell membrane proteins to the cytoskeleton; may play a role in negative regulation of cell growth [RGD, Feb 2006]
Uniprot Description
Merlin: a moesin-ezrin-radizin-like protein. Interacts with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. Expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations are associated with neurofibromatosis type II. Two predominant isoforms and eight minor isoforms are produced by alternatively spliced transcripts.
Protein type: Tumor suppressor; Motility/polarity/chemotaxis; Cytoskeletal
Cellular Component: cortical actin cytoskeleton; protein complex; early endosome; lipid raft; ruffle; extrinsic to membrane; cell projection; adherens junction; cytoskeleton; membrane; perinuclear region of cytoplasm; apical part of cell; lamellipodium; cytoplasm; nucleolus; plasma membrane; synapse; nucleus; filopodium; cleavage furrow
Molecular Function: integrin binding; protein domain specific binding; protein binding; beta-catenin binding; actin binding
Biological Process: intercellular junction assembly and maintenance; negative regulation of MAPKKK cascade; hippocampus development; regulation of protein stability; negative regulation of tyrosine phosphorylation of Stat5 protein; odontogenesis of dentine-containing teeth; regulation of cell proliferation; Schwann cell proliferation; negative regulation of cell proliferation; mesoderm formation; negative regulation of DNA replication; positive regulation of stress fiber formation; ectoderm development; negative regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of protein kinase activity; brain development; negative regulation of cell growth; negative regulation of cell-cell adhesion; positive regulation of cell differentiation; actin cytoskeleton organization and biogenesis; negative regulation of JAK-STAT cascade
Research Articles on NF2
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Product Notes
The Rat NF2 nf2 (Catalog #AAA9338557) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9338557 ELISA Kit recognizes Rat NF2. It is sometimes possible for the material contained within the vial of "neurofibromin 2 (merlin), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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