Endonuclease 8-like 1 (Neil1) Recombinant Protein | Neil1 recombinant protein
Recombinant Mouse Endonuclease 8-like 1 (Neil1)
Gene Names
Neil1; NEH1; Nei1; 2810450N13Rik
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Endonuclease 8-like 1 (Neil1); Recombinant Mouse Endonuclease 8-like 1 (Neil1); Neil1 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
2-389, full length protein
Sequence
PEGPELHLASHFVNETCKGLVFGGCVEKSSVSRNPEVPFESSAYHISALARGKELRLTLSPLPGSQPPQKPLSLVFRFGMSGSFQLVPAEALPRHAHLRFYTAPPAPRLALCFVDIRRFGHWDPGGEWQPGRGPCVLLEYERFRENVLRNLSDKAFDRPICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARTVLEALQQCRPSPELTLSQKIKAKLQNPDLLELCHLVPKEVVQLGGKGYGPERGEEDFAAFRAWLRCYGVPGMSSLRDRHGRTIWFQGDPGPLAPKGGRSQKKKSQETQLGAEDRKEDLPLSSKSVSRMRRARKHPPKRIAQQSEGAGLQQNQETPTAPEKGKRRGQRASTGHRRRPKTIPDTRPREAGESSAS
Sequence Length
388
Species
Mouse
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
28,453 Da
NCBI Official Full Name
endonuclease 8-like 1 isoform 1
NCBI Official Synonym Full Names
nei endonuclease VIII-like 1 (E. coli)
NCBI Official Symbol
Neil1
NCBI Official Synonym Symbols
NEH1; Nei1; 2810450N13Rik
NCBI Protein Information
endonuclease 8-like 1
UniProt Protein Name
Endonuclease 8-like 1
Protein Family
UniProt Gene Name
Neil1
UniProt Synonym Gene Names
Nei1; NEH1
Uniprot Description
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Research Articles on Neil1
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Product Notes
The Neil1 neil1 (Catalog #AAA1485341) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-389, full length protein. The amino acid sequence is listed below: PEGPELHLAS HFVNETCKGL VFGGCVEKSS VSRNPEVPFE SSAYHISALA RGKELRLTLS PLPGSQPPQK PLSLVFRFGM SGSFQLVPAE ALPRHAHLRF YTAPPAPRLA LCFVDIRRFG HWDPGGEWQP GRGPCVLLEY ERFRENVLRN LSDKAFDRPI CEALLDQRFF NGIGNYLRAE ILYRLKIPPF EKARTVLEAL QQCRPSPELT LSQKIKAKLQ NPDLLELCHL VPKEVVQLGG KGYGPERGEE DFAAFRAWLR CYGVPGMSSL RDRHGRTIWF QGDPGPLAPK GGRSQKKKSQ ETQLGAEDRK EDLPLSSKSV SRMRRARKHP PKRIAQQSEG AGLQQNQETP TAPEKGKRRG QRASTGHRRR PKTIPDTRPR EAGESSAS. It is sometimes possible for the material contained within the vial of "Endonuclease 8-like 1 (Neil1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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