Nectin-2 Recombinant Protein | NECTIN2 recombinant protein

Human Nectin-2, soluble

Cat. Num. AAA692514

• Gene Names: NECTIN2; HVEB; PRR2; CD112; PVRL2; PVRR2
• Reactivity: Human
• Synonyms: Nectin-2; Human Nectin-2; soluble; Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Nectin cell adhesion molecule 2; Poliovirus receptor-related protein 2; CD112; NECTIN2 recombinant protein

• Host: E Coli
• Reactivity: Human
• Form/Format: Lyophilized
• Sequence Length: 538

• Tag: His-Tag

Related Product Information for NECTIN2 recombinant protein

Nectins are a small family of Ca++independent immunoglobulin (Ig)-like cell adhesion molecules (CAMs) that organize intercellular junctions. The Nectin family has at least four members, all of which show alternate splicing (except for Nectin-4), a transmembrane (TM) region (except for Nectin-1 gamma), and three extracellular Ig-domains. Nectin-2 is a 60 or 65 kDa type I transmembrane (TM) glycoprotein that is found on a variety of cell types. It has two splice forms. Nectin-2 delta is a 65 kDa long form and is synthesized as a 538 amino acid precursor. It contains a 31 amino acid (aa) signal sequence, a 329 aa extracellular region, a 21 aa TM segment, and a 157 aa cytoplasmic domain. The extracellular region contains one N terminal 85 aa V-type Ig domain and two 45-55 aa C2-type Ig domains. The V-domain is believed to mediate Nectin binding to its ligands. The short, 60 kDa isoform of Nectin-2 (Nectin-2 alpha) has the same signal sequence and extracellular domain as Nectin-2 delta, but differs in the TM and cytoplasmic region. In this case, the cytoplasmic tail is only 94 aa in length. Nectin-2 is known to bind the pseudorabies virus, and herpes simplex virus2 (HSV2), but not HSV1. As a cell adhesion molecule, Nectin-2 will form cis-homodimers (same cell), followed by trans-dimers (across cells). Nectin-2 will not cis-dimerize with other Nectins, but will cis-dimerize with its two splice forms. Notably, a Nectin-2 cis-dimer on one cell will heterodimerize with a Nectin-3 cis-dimer on another cell. Nectin-2 is found concentrated in adherens junctions, and exists on neurons, endothelial cells, epithelial cells and fibroblasts.

Product Categories/Family for NECTIN2 recombinant protein

Soluble receptors

NCBI and Uniprot Product Information

• NCBI GI #: 112789532
• NCBI GeneID: 5819
• NCBI Accession #: NP_001036189.1
• NCBI GenBank Nucleotide #: NM_001042724.1
• UniProt Accession #: Q92692; O75455; Q6IBI6; Q96J29; A8K5L5
• Molecular Weight: 51,359 Da
• NCBI Official Full Name: nectin-2 isoform delta
• NCBI Official Synonym Full Names: nectin cell adhesion molecule 2
• NCBI Official Symbol: NECTIN2
• NCBI Official Synonym Symbols: HVEB; PRR2; CD112; PVRL2; PVRR2
• NCBI Protein Information: nectin-2
• UniProt Protein Name: Nectin-2
• Protein Family: Nectin
• UniProt Gene Name: NECTIN2
• UniProt Synonym Gene Names: Herpesvirus entry mediator B; HveB

NCBI Description

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005).