Human nicastrin ELISA Kit | NCSTN elisa kit
Human Nicastrin, NCSTN ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
Uniprot Description
nicastrin: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Binds to proteolytic processed C-terminal fragments C83 and C99 of the amyloid precursor protein (APP). Constitutively expressed in neural cells. Widely expressed. Belongs to the nicastrin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q22-q23
Cellular Component: Golgi apparatus; focal adhesion; membrane; lysosomal membrane; endoplasmic reticulum; integral to plasma membrane; melanosome; integral to membrane; plasma membrane
Molecular Function: protein binding; endopeptidase activity
Biological Process: positive regulation of catalytic activity; axon guidance; Notch signaling pathway; extracellular matrix organization and biogenesis; membrane protein intracellular domain proteolysis; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; myeloid cell homeostasis; membrane protein ectodomain proteolysis; Notch receptor processing; proteolysis; T cell proliferation; extracellular matrix disassembly; amyloid precursor protein catabolic process; epithelial cell proliferation; beta-amyloid metabolic process; ephrin receptor signaling pathway; protein processing
Disease: Acne Inversa, Familial, 1
Research Articles on NCSTN
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Product Notes
The Human NCSTN ncstn (Catalog #AAA9334840) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334840 ELISA Kit recognizes Human NCSTN. It is sometimes possible for the material contained within the vial of "nicastrin, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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