NCOR2 / Nuclear Receptor Corepressor 2 Recombinant Protein | NCOR2 recombinant protein

Human NCOR2 / Nuclear Receptor Corepressor 2 Recombinant Protein

• Gene Names: NCOR2; SMRT; TRAC; CTG26; SMRTE; TRAC1; N-CoR2; TNRC14; TRAC-1; SMAP270; SMRTE-tau
• Applications: ELISA, Western Blot
• Purity: >95% by SDS-PAGE
• Synonyms: NCOR2 / Nuclear Receptor Corepressor 2; Human NCOR2 / Nuclear Receptor Corepressor 2 Recombinant Protein; Nuclear receptor corepressor 2; N-CoR2; CTG repeat protein 26; SMAP270; Silencing mediator of retinoic acid and thyroid hormone receptor; SMRT; T3 receptor-associating factor; TRAC; Thyroid-; retinoic-acid-receptor-associated corepressor; CTG26; NCOR2 recombinant protein

• Host: E Coli
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
• Concentration: Reconstitution Dependent (varies by lot)
• Sequence Length: 2458

• Applicable Applications for NCOR2 recombinant protein: ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
• Species: Human
• Tag: His
• Subunit: Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity. Interacts (isoform SMRT) with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with CBFA2T3 and ATXN1L. Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity. Interacts with HDAC7 and C1D. Interacts with NR4A2; this interaction increases in the absence of PITX3. Interacts with BCL6 (via the BTB domain), required for BCL6 transcriptional repressor activity on a subset of target genes. Forms ternary complexes with BCOR and BCL6 on target gene promoters but, on enhancer elements, interacts with BCL6 and HDAC3 to repress proximal gene expression. May interact with DEAF1. Interacts with RXRA. Interacts with MECP2.
• Entry Function: Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival.
• Preparation and Storage: Store at -20 degree C. Avoid repeated freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 331284176
• NCBI GeneID: 9612
• NCBI Accession #: NP_001070729.2
• NCBI GenBank Nucleotide #: NP_001070729.2
• UniProt Accession #: Q9Y618
• NCBI Official Full Name: nuclear receptor corepressor 2 isoform 2
• NCBI Official Synonym Full Names: nuclear receptor corepressor 2
• NCBI Official Symbol: NCOR2
• NCBI Official Synonym Symbols: SMRT; TRAC; CTG26; SMRTE; TRAC1; N-CoR2; TNRC14; TRAC-1; SMAP270; SMRTE-tau
• NCBI Protein Information: nuclear receptor corepressor 2
• UniProt Protein Name: Nuclear receptor corepressor 2
• Protein Family: Nuclear receptor corepressor
• UniProt Gene Name: NCOR2
• UniProt Synonym Gene Names: CTG26; N-CoR2; SMRT; TRAC
• UniProt Entry Name: NCOR2_HUMAN

NCBI Description

This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]