Baculoviral IAP repeat-containing protein 1b (Naip2) Recombinant Protein | Naip2 recombinant protein

Recombinant Mouse Baculoviral IAP repeat-containing protein 1b (Naip2) , partial

• Gene Names: Naip2; Birc1b; Naip-rs6
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Baculoviral IAP repeat-containing protein 1b (Naip2); Recombinant Mouse Baculoviral IAP repeat-containing protein 1b (Naip2); partial; Naip2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,447

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 187133243
• NCBI GeneID: 17948
• NCBI Accession #: NP_001119654.1
• NCBI GenBank Nucleotide #: NM_001126182.2
• UniProt Accession #: Q9QUK4; O09124; Q9R030; A9C470
• Molecular Weight: 164,083 Da
• NCBI Official Full Name: baculoviral IAP repeat-containing protein 1b
• NCBI Official Synonym Full Names: NLR family, apoptosis inhibitory protein 2
• NCBI Official Symbol: Naip2
• NCBI Official Synonym Symbols: Birc1b; Naip-rs6
• NCBI Protein Information: baculoviral IAP repeat-containing protein 1b
• UniProt Protein Name: Baculoviral IAP repeat-containing protein 1b
• Protein Family: Baculoviral IAP repeat-containing protein
• UniProt Gene Name: Naip2
• UniProt Synonym Gene Names: Birc1b; Naip-rs6

Uniprot Description

Sensor component of the NLRC4 inflammasome that specifically recognizes and binds type III secretion system (T3SS) rod proteins such as S.typhimurium (Salmonella) PrgJ and B.thailandensis BsaK from pathogenic bacteria. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri. Prevents motor-neuron apoptosis induced by a variety of signals.