Myocilin (Myoc) Recombinant Protein | Myoc recombinant protein

Recombinant Rat Myocilin (Myoc)

Cat. Num. AAA1360080

• Gene Names: Myoc; Tigr
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Myocilin (Myoc); Recombinant Rat Myocilin (Myoc); Myoc recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 32-502, full length protein
• Sequence: RTAQFRKANDRSGRCQYTFTVASPSESSCPREDQAMSAIQDLQRDSSIQHADLESTKARVRSLESLLHQMTSGGVTGTQEVQEGLQGQLGALRRERDQLETQTRDLEVAYNNLLRDKSALEEEKRQLEQENKDLARRLEGSSQEVARLRRGQCPSTHHPSQDMLPGSREVSQWNLDTLAFQELKSELTEVPASQILKNQSGHPRSKEGDKGCGVLMWVGEPVTLRTAETITGKYGVWMRDPKPTHPYTQETTWRIDTVGTGIRQVFEYSQISQFEQGYPSKVHVLPQALESTGAVVYSGSLYFQGAESRTVLRYELNTETVKAEKEIPGAGYHGQFPYAWGGYTDIDLAVDESGLWVIYSTEETRGAIVLSKLNPENLELESTWETNIRKQSVANAFVICGILYTVSSYSSVHATINFAYDTNTGISKTLTIPFKNRYKYSSMVDYNPLERKLFAWDNFNMVTYDIKLSEM
• Sequence Length: 471

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Myoc recombinant protein

MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.

NCBI and Uniprot Product Information

• NCBI GI #: 13540693
• NCBI GeneID: 81523
• NCBI Accession #: NP_110492.1
• NCBI GenBank Nucleotide #: NM_030865.1
• UniProt Accession #: Q9R1J4; Q9Z2Y4
• Molecular Weight: 56,442 Da
• NCBI Official Full Name: myocilin
• NCBI Official Synonym Full Names: myocilin
• NCBI Official Symbol: Myoc
• NCBI Official Synonym Symbols: Tigr
• NCBI Protein Information: myocilin
• UniProt Protein Name: Myocilin
• Protein Family: Myocilin
• UniProt Gene Name: Myoc
• UniProt Synonym Gene Names: Tigr

NCBI Description

gene is associated with the pathogenesis of juvenile-onset primary open angle glaucoma [RGD, Feb 2006]

Uniprot Description

Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.