Human mitochondrial E3 ubiquitin ligase 1 ELISA Kit | MUL1 elisa kit
Human Mitochondrial ubiquitin ligase activator of NFKB 1, MUL1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
MULAN: Exhibits weak E3 ubiquitin-protein ligase activity, but preferentially acts as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Protein type: EC 6.3.2.-; Ligase; EC 6.3.2.19; Mitochondrial; Membrane protein, integral; Apoptosis; Ubiquitin ligase; Ubiquitin conjugating system; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1p36.12
Cellular Component: nucleoplasm; membrane; mitochondrion; cytoplasm; peroxisome; integral to mitochondrial outer membrane
Molecular Function: identical protein binding; protein binding; signal transducer activity; zinc ion binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; SUMO ligase activity; ligase activity
Biological Process: caspase activation; mitochondrial fission; negative regulation of protein kinase B signaling cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein stabilization; protein ubiquitination; negative regulation of defense response to virus by host; mitochondrion localization; activation of JNK activity; positive regulation of protein sumoylation; protein sumoylation; negative regulation of innate immune response; negative regulation of cell growth
Research Articles on MUL1
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Product Notes
The Human MUL1 mul1 (Catalog #AAA9326504) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9326504 ELISA Kit recognizes Human MUL1. It is sometimes possible for the material contained within the vial of "mitochondrial E3 ubiquitin ligase 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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