Mouse myotubularin related protein 3 ELISA Kit | MTMR3 elisa kit
Mouse Myotubularin-related protein 3, MTMR3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
MTMR3: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.3.64; Motility/polarity/chemotaxis; EC 3.1.3.48; EC 3.1.3.95; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: nucleoplasm; extrinsic to membrane; membrane; cytoplasm; cytosol
Molecular Function: phosphatidylinositol-3-phosphatase activity; metal ion binding; protein tyrosine phosphatase activity; protein serine/threonine phosphatase activity
Biological Process: phospholipid metabolic process; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; protein amino acid dephosphorylation
Research Articles on MTMR3
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Product Notes
The Mouse MTMR3 mtmr3 (Catalog #AAA9316809) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9316809 ELISA Kit recognizes Mouse MTMR3. It is sometimes possible for the material contained within the vial of "myotubularin related protein 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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