Myostatin Recombinant Protein | MSTN recombinant protein

Recombinant Human Myostatin, HEK

Cat. Num. AAA140866

• Gene Names: MSTN; GDF8; MSLHP
• Purity: Purity as determined by densitometric image analysis is greater than 95%.
• Synonyms: Myostatin; Recombinant Human Myostatin; HEK; Myostatin Human; Myostatin Human Recombinant; GDF-8; MSTN; Growth Differentiation Factor 8; MSTN Muscle Hypertrophy; MSTN recombinant protein

• Host: HEK 293
• Purity/Purification: Purity as determined by densitometric image analysis is greater than 95%.
• Form/Format: Myostatin solution at a concentration of 0.25mg/ml in phosphate buffered saline (PBS) pH 8.0 and 20% (w/v) glycerol.; Filtered colorless solution.
• Sequence: HHHHHHASNE NSEQKENVEK EGLCNACTWR QNTKSSRIEA IKIQILSKLR LETAPNISKD VIRQLLPKAP PLRELIDQYD VQRDDSSDGS LEDDDYHATT ETIITMPTES DFLMQVDGKP KCCFFKFSSK IQYNKVVKAQ LWIYLRPVET PTTVFVQILR LIKPMKDGTR YTGIRSLKLD MNPGTGIWQS IDVKTVLQNW LKQPESNLGI EIKALDENGH DLAVTFPGPG EDGLNPFLEV KVTDTPKRSR RDFGLDCDEH STESRCCRYP LTVDFEAFGW DWIIAPKRYK ANYCSGECEF VFLQKYPHTH LVHQANPRGS AGPCCTPTKM SPINMLYFNG KEQIIYGKIP AMVVDRCGCS.
• Sequence Length: 375

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Related Product Information for MSTN recombinant protein

Introduction: GDF8 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.

Description: Myostatin Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain (Asn24-Ser375) containing a total of 360 amino acids, having a calculated molecular mass of 41.1kDa. Myostatin is fused to a 2 aa N-terminal linker and a 6 aa His tag at N-Terminus.

Product Categories/Family for MSTN recombinant protein

Cytokines and Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 4885259
• NCBI GeneID: 2660
• NCBI Accession #: NP_005250.1
• NCBI GenBank Nucleotide #: NM_005259.2
• UniProt Accession #: O14793; Q6B0H2; A1C2J7; A1C2K0
• Molecular Weight: 42,750 Da
• NCBI Official Full Name: growth/differentiation factor 8 preproprotein
• NCBI Official Synonym Full Names: myostatin
• NCBI Official Symbol: MSTN
• NCBI Official Synonym Symbols: GDF8; MSLHP
• NCBI Protein Information: growth/differentiation factor 8
• UniProt Protein Name: Growth/differentiation factor 8
• Protein Family: Growth/differentiation factor
• UniProt Gene Name: MSTN
• UniProt Synonym Gene Names: GDF8; GDF-8
• UniProt Entry Name: GDF8_HUMAN

Uniprot Description

MSTN: Acts specifically as a negative regulator of skeletal muscle growth. Defects in MSTN are the cause of muscle hypertrophy (MSLHP). MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q32.2

Cellular Component: extracellular space

Molecular Function: cytokine activity; identical protein binding; protein binding; receptor binding; transforming growth factor beta receptor binding

Biological Process: cell development; muscle development; muscle maintenance; negative regulation of myoblast differentiation; negative regulation of protein kinase B signaling cascade; negative regulation of skeletal muscle growth; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade

Disease: Muscle Hypertrophy