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Testing Data (The OmniKine Human IGF-1R ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human IGF-1R proteins within the range of 250-16000 pg/ml.)

Human IGF-1R ELISA Kit | IGF-1R elisa kit

IGF-1R (Human) OmniKine ELISA Kit

Gene Names
IGF1R; IGFR; CD221; IGFIR; JTK13
Reactivity
Human
Synonyms
IGF-1R; IGF-1R (Human) OmniKine ELISA Kit; Insulin-like growth factor 1 receptor; CD221; IGF-1R elisa kit
Ordering
For Research Use Only!
Reactivity
Human
Specificity
The OmniKine Human IGF-1R ELISA is capable of recognizing both recombinant and naturally produced Human IGF-1R proteins. The antigens listed below were tested at 50 ng/ml and did not exhibit significant cross reactivity or interference.
Human: IGF-1, IGF-2, IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, IGFBP-6, IL-3 sR, IL-9 sR, TGF-sR2
Form/Format
12 x 8-Well Microstrips
Sequence Length
1367
Samples
Plasma, serum, lysate
Assay Type
Sandwich ELISA
Detection Range
250-16000 pg/ml
Sensitivity
250-16000 pg/ml
Detection Method
Colorimetric 450 nm
Subtype
None
Preparation and Storage
Store at 4 degree C for 6 months.

Testing Data

(The OmniKine Human IGF-1R ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human IGF-1R proteins within the range of 250-16000 pg/ml.)

Testing Data (The OmniKine Human IGF-1R ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human IGF-1R proteins within the range of 250-16000 pg/ml.)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
154,793 Da
NCBI Official Full Name
insulin-like growth factor 1 receptor isoform 1
NCBI Official Synonym Full Names
insulin like growth factor 1 receptor
NCBI Official Symbol
IGF1R
NCBI Official Synonym Symbols
IGFR; CD221; IGFIR; JTK13
NCBI Protein Information
insulin-like growth factor 1 receptor
UniProt Protein Name
Insulin-like growth factor 1 receptor
UniProt Gene Name
IGF1R
UniProt Synonym Gene Names
IGF-I receptor

NCBI Description

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Uniprot Description

IGF1R: a receptor tyrosine kinase that binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. Functions as an anti-apoptotic agent by enhancing cell survival. Can play a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Mutated in rare cases of pre- and post-natal growth retardation. One SNP associated with increased human longevity. Increased expression of IGF1R and other pathway members associated with progression and malignancy in a range of cancers. Inhibitors: AG1024, AEW541.

Protein type: EC 2.7.10.1; InsR family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Chromosomal Location of Human Ortholog: 15q26.3

Cellular Component: integral component of plasma membrane; intracellular membrane-bound organelle; membrane; plasma membrane; receptor complex

Molecular Function: ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor-activated receptor activity; phosphoinositide 3-kinase binding; protein binding; protein tyrosine kinase activity

Biological Process: cellular response to amyloid-beta; immune response; inactivation of MAPKK activity; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; negative regulation of apoptosis; peptidyl-tyrosine autophosphorylation; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of protein complex disassembly; protein autophosphorylation; protein tetramerization; regulation of JNK cascade; signal transduction

Disease: Insulin-like Growth Factor I, Resistance To

Research Articles on IGF-1R

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Product Notes

The Human IGF-1R igf1r (Catalog #AAA9501952) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501952 ELISA Kit recognizes Human IGF-1R. It is sometimes possible for the material contained within the vial of "IGF-1R, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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